Probiotic & Fiber · Other

Clostridium butyricum MIYAIRI 588

Provisional Strong Scoreprobiotic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Clostridium butyricum MIYAIRI 588 is a spore-forming probiotic strain that produces butyric acid in the colon to support digestive health and immune function. This beneficial bacterium strengthens the intestinal barrier and modulates inflammatory responses through short-chain fatty acid production.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryProbiotic & Fiber

GroupOther

Public Score StatusProvisional Strong

Primary KeywordClostridium butyricum MIYAIRI 588 benefits

Clostridium butyricum MIYAIRI 588 close-up macro showing natural texture and detail — rich in butyrate production, gut microbiota modulation, anti-inflammatory

Clostridium butyricum MIYAIRI 588 — botanical close-up

Reported Benefits (Provisional)

Enhances gut health by producing butyric acid, which nourishes colon cells and improves bowel regularity. This promotes a healthy digestive system. - Reduces inflammation by modulating immune responses, potentially lowering the risk of chronic inflammatory diseases. - Supports metabolic health by influencing fat metabolism, which can aid in weight management. - Boosts immune function by stimulating the production of beneficial short-chain fatty acids, enhancing the body's defense mechanisms. - Improves mental clarity by interacting with the gut-brain axis, potentially reducing symptoms of anxiety and depression. - Supports liver health by reducing liver fat accumulation, promoting detoxification processes. - Enhances skin health by reducing systemic inflammation, leading to clearer, more radiant skin.

Origin & History

Natural habitat

Clostridium butyricum is a spore-forming bacterium naturally found in the human gut and soil. It is cultured for use in supplements to support digestive health and balance gut flora.

“Clostridium butyricum has been used in traditional Asian medicine for its digestive benefits and is now gaining popularity in Western probiotic formulations.”Traditional Medicine

Research Narrative (Provisional)

Research, including RCTs, indicates that Clostridium butyricum can help improve gut health and treat conditions like irritable bowel syndrome and ulcerative colitis.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

Reported Mechanism (Provisional)

Mechanism of Action

Clostridium butyricum MIYAIRI 588 ferments dietary fiber to produce butyric acid, which serves as the primary energy source for colonocytes and strengthens tight junction proteins in the intestinal barrier. Butyric acid activates GPR41 and GPR43 receptors on immune cells, promoting regulatory T-cell differentiation and reducing pro-inflammatory cytokine production. The strain also produces vitamin B12 and competes with pathogenic bacteria for colonization sites.

Clinical Narrative (Provisional)

Human studies with Clostridium butyricum MIYAIRI 588 include randomized controlled trials in patients with irritable bowel syndrome and antibiotic-associated diarrhea. A 12-week study of 60 IBS patients showed 40% improvement in abdominal pain scores compared to placebo. Research in elderly patients demonstrated reduced duration of antibiotic-associated diarrhea from 5.2 to 2.8 days. However, most clinical evidence comes from small-scale studies, and larger trials are needed to confirm therapeutic benefits.

Also Known As

Clostridium butyricumC. butyricumCBM 588Miyairi 588Butyric acid bacteriaSpore-forming probioticClostridial probiotic

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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