Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Clostridium butyricum is a probiotic bacterium renowned for its ability to produce butyrate, a crucial short-chain fatty acid. This mechanism, along with its synthesis of antimicrobial peptides, supports gut barrier integrity and modulates immune responses.
Reported Benefits (Provisional)
Origin & History
Clostridium butyricum is a spore-forming, anaerobic probiotic bacterium naturally found in the mammalian gut microbiota and soil. It is distinguished by its unique ability to produce butyrate, a crucial short-chain fatty acid. This beneficial microbe is widely utilized in functional foods and supplements for its profound impact on gut health and systemic wellness.
Research Narrative (Provisional)
Research on Clostridium butyricum primarily focuses on its role in gut health, immune modulation, and inflammation reduction, with a growing body of evidence from in vitro, animal, and human studies. Preliminary clinical trials support its efficacy in managing various gastrointestinal disorders and influencing the brain-gut axis.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Butyrate: A short-chain fatty acid produced by the bacterium, crucial for colonocyte energy, gut barrier function, and anti-inflammatory signaling.
Reported Mechanism (Provisional)
Clostridium butyricum's primary mechanism involves the robust production of butyrate, a crucial short-chain fatty acid, at concentrations around 3.4 g/L under fermentation conditions, which strengthens intestinal barrier integrity and supports gut microbiota. Additionally, it synthesizes specific antimicrobial peptides (CBP) that directly inhibit common pathogenic bacteria such as *E. coli K88*, *Salmonella spp.*, and *S. aureus*, contributing to enhanced host defenses. Its immunomodulatory effects also involve reducing systemic inflammation.
Clinical Narrative (Provisional)
Research on Clostridium butyricum highlights its role in gut health, immune modulation, and inflammation reduction through a growing body of evidence. Studies include in vitro, animal models, and preliminary human investigations, demonstrating its efficacy in strengthening the intestinal barrier and supporting microbiota diversity. While preliminary clinical trials support its use in managing various gastrointestinal disorders, specific sample sizes and comprehensive phase III trial data are often limited.
Also Known As
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