Amino Acid & Peptide · Compound

CJC-1295

Provisional Moderate Scoreamino_acid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

CJC-1295 is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that binds to growth hormone secretagogue receptors. It stimulates sustained growth hormone release for up to 7 days, promoting muscle growth and fat metabolism.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary KeywordCJC-1295 benefits

CJC-1295 close-up macro showing natural texture and detail — rich in growth hormone releasing hormone analog, anabolic, lipolytic

CJC-1295 — botanical close-up

Reported Benefits (Provisional)

Stimulates sustained release of growth hormone (GH), promoting continuous muscle growth and fat metabolism. - Enhances muscle mass and strength by increasing protein synthesis and reducing muscle catabolism. - Supports fat loss by boosting lipolysis and metabolic rate, aiding in body composition improvements. - Improves sleep quality, which is vital for hormone regulation and tissue repair. - Increases cellular regeneration and repair, accelerating recovery from exercise and injury. - Promotes bone density and joint health by stimulating osteoblast activity. - May improve skin elasticity and reduce signs of aging through increased collagen production. - Offers long-acting effects with a single weekly dose, making it convenient for busy lifestyles.

Origin & History

CJC-1295 growing in natural environment — cultivated since 1295

Natural habitat

CJC-1295 is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analog. It is produced through peptide synthesis and is used for its potential to increase growth hormone levels.

“Developed in the early 2000s, CJC-1295 is used in research for its potential anti-aging and performance-enhancing effects.”Traditional Medicine

Research Narrative (Provisional)

CJC-1295 has been studied in animal models and early human trials, showing potential for sustained growth hormone release. Further research is required.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Composed of a sequence of amino acids. - Administered via subcutaneous injection. - Long-acting due to its ability to bind to albumin.

Reported Mechanism (Provisional)

Mechanism of Action

CJC-1295 binds to growth hormone secretagogue receptors (GHSR) in the anterior pituitary gland, triggering cyclic adenosine monophosphate (cAMP) signaling pathways. This stimulates somatotroph cells to release growth hormone in pulsatile patterns. The peptide's lysine modification allows it to bind to albumin, extending its half-life to approximately 6-8 days compared to natural GHRH's 7-minute half-life.

Clinical Narrative (Provisional)

Limited human studies exist for CJC-1295, with most research conducted on small cohorts of 10-20 participants. One study in healthy adults showed 2-10 fold increases in growth hormone levels lasting up to 6 days after injection. Animal studies demonstrate improved body composition with increased lean mass and reduced fat mass over 4-8 week periods. However, long-term safety data and large-scale clinical trials are lacking, limiting evidence quality.

Also Known As

CJC-1295 DACCJC-1295 without DACModified GRF 1-29Mod GRF 1-29GHRH analogGrowth hormone releasing peptide analogCJC1295

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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