Extract & Compound · Other

Cetyl Myristoleate (CMO)

Provisional Moderate Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Cetyl myristoleate is a fatty acid ester that acts as an immunomodulator and anti-inflammatory agent, primarily targeting joint tissue. It works by modulating immune cell function and enhancing synovial fluid production to reduce joint inflammation and improve mobility.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordcetyl myristoleate benefits

Cetyl Myristoleate close-up macro showing natural texture and detail — rich in anti-inflammatory, immunomodulatory, lubricant

Cetyl Myristoleate (CMO) — botanical close-up

Reported Benefits (Provisional)

May reduce joint inflammation and pain associated with arthritis, improving mobility and quality of life. - Supports joint lubrication and flexibility, which can enhance physical performance and comfort. - Enhances cartilage health by promoting repair and regeneration, potentially delaying the onset of degenerative joint diseases. - Supports immune health by modulating inflammatory pathways, reducing the risk of autoimmune flare-ups. - Promotes skin health by improving elasticity and hydration, leading to a more youthful appearance. - May improve cardiovascular health by reducing inflammation, which can lead to better heart function and reduced risk of disease. - Supports bone health by enhancing calcium absorption, which can strengthen bones and reduce the risk of fractures.

Origin & History

Natural habitat

Cetyl myristoleate (CMO) is a fatty acid ester derived from myristoleic acid, found in certain animal fats and plant oils. It is typically synthesized in laboratories for use in supplements.

“CMO was discovered in the 1970s and has since been used as a natural remedy for joint pain, particularly in alternative medicine circles.”Traditional Medicine

Research Narrative (Provisional)

Some clinical trials and animal studies suggest benefits for joint health and inflammation reduction, but more research is needed to confirm efficacy.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains fatty acids beneficial for joint health. - Often combined with other joint-supporting nutrients in supplements. - Available in capsule or cream form for topical application.

Reported Mechanism (Provisional)

Mechanism of Action

Cetyl myristoleate modulates T-cell function and suppresses pro-inflammatory cytokines like TNF-alpha and IL-1 beta. It enhances synovial fluid production by stimulating hyaluronic acid synthesis and acts on cell membrane fluidity to reduce inflammatory responses. The compound also inhibits complement cascade activation, reducing tissue damage in arthritic joints.

Clinical Narrative (Provisional)

Small human studies with 30-60 participants have shown cetyl myristoleate supplementation (500-1000mg daily) may reduce joint pain scores by 40-60% over 8-12 weeks. One controlled trial found improved range of motion and decreased morning stiffness in osteoarthritis patients. However, most research consists of preliminary studies with limited sample sizes, and larger randomized controlled trials are needed to confirm therapeutic efficacy.

Also Known As

Cetyl (Z)-tetradec-9-enoateCMOCetyl-9-tetradecenoateMyristoleic acid cetyl esterCetyl myristolateC30H58O2

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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