Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Celastrol is a triterpene compound from Tripterygium wilfordii that demonstrates potent anti-inflammatory activity through inhibition of NF-κB signaling pathways. This bioactive compound also modulates leptin sensitivity and heat shock protein responses to support weight management and joint health.
Reported Benefits (Provisional)
Origin & History
Celastrol is a triterpene extracted from the root bark of the Thunder God Vine (Tripterygium wilfordii), a plant native to China. It is typically isolated through solvent extraction and purification processes.
Research Narrative (Provisional)
Research includes preclinical studies and some human trials focusing on its anti-inflammatory and anti-cancer properties. Further RCTs are needed to confirm efficacy in humans.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Contains active triterpene compounds. - Exhibits potent anti-inflammatory properties. - Acts as a natural antioxidant.
Reported Mechanism (Provisional)
Celastrol inhibits nuclear factor-κB (NF-κB) translocation, reducing production of inflammatory cytokines including TNF-α, IL-1β, and IL-6. The compound also activates heat shock factor 1 (HSF1) and enhances leptin sensitivity in the hypothalamus, promoting satiety and increased energy expenditure. Additionally, celastrol modulates AMPK signaling pathways and inhibits proteasome activity.
Clinical Narrative (Provisional)
Limited human clinical trials exist for celastrol, with most evidence derived from animal and in vitro studies. Preclinical studies in rodents show 40% reductions in inflammatory markers and significant weight loss at doses of 100-200 mcg/kg daily. Small pilot studies in humans suggest anti-inflammatory effects, but larger randomized controlled trials are needed. Current evidence is promising but preliminary for most therapeutic applications.
Also Known As
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