Extract & Compound · Compound

Cannabidiol (CBD)

Provisional Strong Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Cannabidiol (CBD) is a non-psychoactive cannabinoid that primarily interacts with CB1 and CB2 receptors in the endocannabinoid system. It modulates neurotransmitter activity and inflammatory responses to provide therapeutic effects for anxiety, pain, and neurological conditions.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Strong

Primary KeywordCBD benefits

Cannabidiol (CBD) — botanical close-up

Reported Benefits (Provisional)

Reduces anxiety by interacting with serotonin receptors, which can decrease anxiety levels by up to 60% in some studies. - Alleviates chronic pain and inflammation through its anti-inflammatory properties, providing relief for conditions like arthritis. - Supports mental health by enhancing endocannabinoid system function, which can improve mood and cognitive function. - Promotes better sleep quality by reducing insomnia symptoms, leading to a 30% improvement in sleep duration. - Enhances focus and concentration by modulating neurotransmitter release, aiding in clearer thinking and productivity. - Supports cardiovascular health by reducing blood pressure and improving circulation. - Boosts immune function by modulating immune responses, helping the body fight off infections more effectively.

Origin & History

Natural habitat

Cannabidiol (CBD) is a non-psychoactive compound extracted from the hemp plant, a variety of Cannabis sativa. It is typically obtained through CO2 extraction to ensure purity.

“CBD has been used for centuries in traditional medicine, gaining modern popularity in the 21st century for its therapeutic potential without psychoactive effects.”Traditional Medicine

Research Narrative (Provisional)

Numerous RCTs and meta-analyses support CBD's efficacy in reducing anxiety, pain, and seizure frequency. Ongoing research continues to explore its full potential.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains cannabinoids interacting with the endocannabinoid system. - Non-psychoactive and legal in many regions. - Often available in oils, capsules, and topical forms.

Reported Mechanism (Provisional)

Mechanism of Action

CBD acts as a negative allosteric modulator of CB1 receptors and partial agonist of CB2 receptors in the endocannabinoid system. It enhances anandamide levels by inhibiting fatty acid amide hydrolase (FAAH) and interacts with serotonin 5-HT1A receptors to regulate mood and anxiety. CBD also activates TRPV1 vanilloid receptors and inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain perception.

Clinical Narrative (Provisional)

Randomized controlled trials with 24-57 participants demonstrate CBD's anxiolytic effects, with studies showing 37-60% reduction in social anxiety symptoms at doses of 300-600mg. Pain studies involving 214-799 participants with chronic conditions report 30-50% improvement in pain scores with topical and oral CBD formulations. However, most studies are small-scale and short-term, with larger long-term trials needed to establish definitive therapeutic protocols and optimal dosing regimens.

Also Known As

Cannabis sativa L. extractHemp extractPhytocannabinoidNon-psychoactive cannabis compoundHemp-derived cannabidiolIndustrial hemp extractCBD isolate

Browse All Ingredients More Compound About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.