Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Caffeine anhydrous is a dehydrated form of caffeine that blocks adenosine receptors in the brain to enhance alertness and physical performance. This stimulant increases dopamine and norepinephrine levels while promoting fat oxidation through phosphodiesterase inhibition.
Reported Benefits (Provisional)
Origin & History
Caffeine Anhydrous is a dehydrated form of caffeine, providing a concentrated dose of this natural stimulant commonly found in coffee and tea.
Research Narrative (Provisional)
Extensive research supports caffeine's efficacy in enhancing alertness and athletic performance, with numerous RCTs validating its benefits.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Caffeine Anhydrous (1,3,7-trimethylxanthine) is a purified, dehydrated form of caffeine with approximately 0.5% or less moisture content, making it ~20% more concentrated by weight than caffeine found in coffee. It contains no macronutrients (0g protein, 0g fat, 0g carbohydrates), no dietary fiber, no vitamins, and no minerals in meaningful quantities. The primary bioactive compound is caffeine itself, typically present at 99%+ purity in supplement-grade powder. Standard dosing in supplements ranges from 100–200mg per serving, with some pre-workouts containing up to 300–400mg. As a xanthine alkaloid, it also contains trace structural relatives including minor xanthine derivatives depending on manufacturing source. Bioavailability is high: caffeine anhydrous is rapidly and nearly completely absorbed from the gastrointestinal tract, with bioavailability approaching 100%. Peak plasma concentrations are reached within 30–60 minutes of ingestion, faster than caffeine from beverages due to absence of water and binding compounds. Half-life ranges from 3–7 hours depending on individual metabolic rate (CYP1A2 enzyme activity). It is lipid- and water-soluble, allowing it to cross the blood-brain barrier efficiently. No caloric value. No significant fiber, antioxidant polyphenols, or chlorogenic acids are present, distinguishing it from whole coffee or tea sources.
Reported Mechanism (Provisional)
Caffeine anhydrous acts as an adenosine receptor antagonist, preventing adenosine from binding to A1 and A2A receptors in the brain, which normally promote sleepiness. It inhibits phosphodiesterase enzymes, increasing cyclic adenosine monophosphate (cAMP) levels, which enhances lipolysis and thermogenesis. Additionally, it increases dopamine and norepinephrine release in the central nervous system, improving mood and cognitive function.
Clinical Narrative (Provisional)
Randomized controlled trials with 200-400mg caffeine anhydrous show 3-7% improvements in endurance performance and 11-12% increases in fat oxidation during exercise. Meta-analyses of cognitive studies demonstrate significant improvements in attention, reaction time, and working memory within 30-60 minutes of consumption. Weight loss studies indicate 2-4% increases in metabolic rate lasting 2-3 hours post-ingestion. Evidence quality is considered moderate to high for performance and cognitive benefits, with most studies using healthy adult populations of 15-50 participants.
Also Known As
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