Leaf & Herb · Other

Bupleurum (Chai Hu)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Bupleurum chinense contains saikosaponins that support liver function by enhancing bile production and reducing hepatic inflammation. These bioactive compounds also modulate immune responses through cytokine regulation and provide antioxidant protection against cellular damage.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryLeaf & Herb

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordbupleurum benefits

Bupleurum (Chai Hu) — botanical close-up

Reported Benefits (Provisional)

Supports liver health and detoxification by enhancing bile flow and reducing liver inflammation, promoting optimal liver function. - May improve immune function by modulating cytokine production, enhancing the body's defense mechanisms. - Contains antioxidants that protect cells from oxidative stress, reducing the risk of chronic illnesses. - Enhances stress resilience by balancing cortisol levels, promoting mental and emotional well-being. - Supports digestive health by soothing the gastrointestinal tract, reducing symptoms of discomfort and bloating. - May improve respiratory health by reducing inflammation in the airways, aiding those with asthma or bronchitis. - Promotes hormonal balance by supporting the endocrine system, potentially alleviating symptoms of hormonal imbalances.

Origin & History

Natural habitat

Bupleurum, also known as Chai Hu, is a plant native to East Asia. The roots are harvested and used in traditional Chinese medicine, often processed into powders or extracts.

“Used for thousands of years in Chinese herbal medicine, Bupleurum is a key ingredient in many traditional formulas for liver and immune health.”Traditional Medicine

Research Narrative (Provisional)

Preliminary studies and some clinical trials suggest its potential in liver support and immune enhancement, but more research is needed.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in saikosaponins. - Contains flavonoids and polysaccharides. - Provides essential fatty acids.

Reported Mechanism (Provisional)

Mechanism of Action

Saikosaponins in bupleurum enhance liver function by stimulating bile acid synthesis through activation of cholesterol 7α-hydroxylase and promoting hepatic glutathione production. These compounds modulate immune responses by regulating NF-κB pathways and reducing pro-inflammatory cytokines like TNF-α and IL-1β. Additionally, saikosaponins demonstrate antioxidant activity by scavenging free radicals and upregulating antioxidant enzymes.

Clinical Narrative (Provisional)

Human clinical trials on bupleurum-containing formulas show modest liver protective effects, with studies of 60-120 participants demonstrating 15-25% improvements in liver enzyme markers over 8-12 weeks. A randomized controlled trial of 89 patients with chronic hepatitis showed significant reductions in ALT and AST levels compared to placebo. However, most research focuses on traditional formulas rather than isolated bupleurum, limiting conclusions about the herb's individual efficacy. Evidence quality ranges from moderate to low due to small sample sizes and methodological limitations.

Also Known As

Bupleurum chinenseBupleurum falcatumChinese ThoroughwaxHare's Ear RootThorow-waxSickle-leaf Hare's-earBei Chai HuNan Chai Hu

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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