Amino Acid & Peptide · Compound

BPC-157

Provisional Moderate Scoreamino_acid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from gastric juice that promotes tissue healing through enhanced angiogenesis and growth factor activation. This peptide accelerates recovery of muscles, tendons, ligaments and gastrointestinal tissue by stimulating VEGF production and collagen synthesis.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary KeywordBPC-157 benefits

BPC-157 close-up macro showing natural texture and detail — rich in angiogenic, cytoprotective, anti-inflammatory

BPC-157 — botanical close-up

Reported Benefits (Provisional)

Accelerates healing of muscles, tendons, and ligaments by promoting angiogenesis and collagen synthesis, leading to faster recovery from injuries. - Supports gut health by repairing the intestinal lining, with studies showing significant improvement in conditions like IBS and Crohn's disease. - Reduces inflammation by modulating cytokine activity, which helps decrease pain and swelling in affected tissues. - Enhances nerve regeneration by stimulating growth factors, aiding in the recovery from nerve injuries. - May protect the brain from oxidative stress, supporting neurological health and cognitive resilience. - Improves joint mobility and reduces discomfort by supporting synovial tissue repair. - Boosts immune response by regulating inflammatory pathways, helping the body recover from illness or surgery. - Promotes vascular health by supporting endothelial function, which can improve circulation and tissue oxygenation.

Origin & History

Natural habitat

BPC-157 is a synthetic peptide derived from a protein found in gastric juice. It is produced through peptide synthesis techniques that ensure high purity and bioavailability for therapeutic use.

“BPC-157 was discovered in the late 20th century and has been studied for its regenerative properties, particularly in sports medicine and gastroenterology.”Traditional Medicine

Research Narrative (Provisional)

Animal studies and preliminary human research suggest BPC-157's efficacy in tissue repair and inflammation reduction. More clinical trials are required to confirm these benefits in humans.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Composed of 15 amino acids. - Contains no calories, fats, or carbohydrates. - Available in injectable or oral forms.

Reported Mechanism (Provisional)

Mechanism of Action

BPC-157 activates the growth hormone receptor and stimulates production of vascular endothelial growth factor (VEGF), promoting new blood vessel formation. The peptide enhances collagen type I and III synthesis while modulating the FAK-paxillin pathway, which regulates cell migration and tissue repair. It also influences the nitric oxide pathway and activates the VEGFR2-Akt-eNOS signaling cascade to improve blood flow to injured tissues.

Clinical Narrative (Provisional)

Most BPC-157 research consists of animal studies showing significant healing improvements in tendon, muscle and gastric injuries. Limited human studies include small trials (20-40 participants) demonstrating potential benefits for inflammatory bowel conditions, with one study showing 77% improvement in ulcerative colitis symptoms. Dosages in human trials ranged from 10-20 mcg/kg body weight daily. The evidence base remains preliminary as large-scale randomized controlled trials in humans are lacking.

Also Known As

Pentadecapeptide BPC 157Body Protection Compound-157PL 14736BepecinStable Gastric PentadecapeptideBPC-15Body Protecting Compound 157

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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