Amino Acid & Peptide · Compound

Agmatine Sulfate

Provisional Moderate Scoreamino_acid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Agmatine sulfate is a metabolite of L-arginine that modulates NMDA receptors and nitric oxide synthase pathways in the brain. This amino acid derivative supports cognitive function, mood regulation, and neuroprotection through its actions on neurotransmitter systems.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordagmatine sulfate benefits

Agmatine Sulfate — botanical close-up

Reported Benefits (Provisional)

Supports cognitive function and mental clarity by modulating NMDA receptors and enhancing synaptic plasticity. - May help alleviate symptoms of depression and anxiety by regulating monoamine neurotransmitters, with studies showing significant mood improvements. - Promotes neuroprotection by reducing oxidative stress and inflammation in the brain. - Enhances pain relief by inhibiting pain signaling pathways, potentially reducing chronic pain by up to 30%. - Supports healthy blood pressure by promoting nitric oxide production and vascular relaxation. - May improve insulin sensitivity and metabolic health, supporting balanced blood sugar levels. - Boosts motivation and focus by influencing key neurotransmitter systems. - Contributes to overall brain resilience and adaptability under stress.

Origin & History

Natural habitat

Agmatine sulfate is a naturally occurring compound derived from the amino acid arginine. It is produced through a decarboxylation process, resulting in a stable form used in dietary supplements.

“Agmatine was discovered in the early 20th century and has been studied for its neuromodulatory properties, gaining interest in sports and mental health communities.”Traditional Medicine

Research Narrative (Provisional)

Preliminary studies, including in vitro and animal research, suggest agmatine's potential in neuroprotection and pain management. Human trials are limited but promising.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Derived from arginine, contains no calories, fats, or carbohydrates. - Available in doses ranging from 500 mg to 2 g. - Acts as a neurotransmitter and neuromodulator.

Reported Mechanism (Provisional)

Mechanism of Action

Agmatine sulfate acts as an endogenous ligand for imidazoline receptors and blocks NMDA receptors, particularly at the polyamine binding site. It inhibits nitric oxide synthase enzymes and modulates calcium channels, affecting neurotransmitter release. The compound also influences serotonin, norepinephrine, and dopamine pathways through its interaction with monoamine oxidase and various receptor subtypes.

Clinical Narrative (Provisional)

Human studies on agmatine sulfate are limited, with most evidence coming from animal models and small-scale trials. A pilot study of 13 depression patients showed mood improvements with 2-3g daily dosing over 3 weeks. Rodent studies demonstrate neuroprotective effects and enhanced learning at doses of 10-100 mg/kg. The clinical evidence remains preliminary, requiring larger randomized controlled trials to establish therapeutic efficacy and optimal dosing protocols.

Also Known As

N-(4-aminobutyl)guanidine sulfateAgmatine sulphateAGM1-Amino-4-guanidinobutane sulfateDecarboxylated arginine4-Guanidinobutylamine sulfate

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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