MODERATE — Monitor Closely
CAUTION — do not combine sleep aids
Evidence level: STRONG
Taking Benadryl with Ambien causes dangerously excessive sedation and impaired coordination.
Additive CNS depression. Both are sedating through different mechanisms.
Never combine two sedating agents for sleep. Choose one or the other.
Take Zolpidem and Diphenhydramine as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Elderly, concurrent alcohol, other CNS depressants
Extreme drowsiness, impaired coordination, sleepwalking, amnesia, confusion
Tell your doctor if you are combining sleep aids.
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Taking Benadryl with Ambien causes dangerously excessive sedation and impaired coordination.
Take Zolpidem and Diphenhydramine as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Extreme drowsiness, impaired coordination, sleepwalking, amnesia, confusion
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Tell your doctor if you are combining sleep aids.
Or browse the full interaction database (121,000+ pairs).