MAJOR — Use With Caution
DANGEROUS — FDA Black Box Warning
Evidence level: STRONG
Suboxone with Ativan carries FDA Black Box warning — still dangerous despite buprenorphine being a partial agonist.
FDA Black Box Warning: opioid + benzodiazepine. Risk remains significant despite buprenorphine ceiling effect.
Avoid if possible. Closest monitoring if unavoidable.
FDA BLACK BOX WARNING: Combining benzodiazepines with opioids can cause profound sedation, respiratory depression, coma, and death. If both are prescribed, your doctor has determined the benefit outweighs significant risk. Take exactly as prescribed — never take extra doses. Do not drive or operate machinery. Seek emergency help for extreme drowsiness, slow/difficult breathing.
High benzo doses, concurrent alcohol, IV misuse
Excessive sedation, respiratory depression, death
FDA Black Box Warning. Coordinate care between prescribers.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Suboxone with Ativan carries FDA Black Box warning — still dangerous despite buprenorphine being a partial agonist.
FDA BLACK BOX WARNING: Combining benzodiazepines with opioids can cause profound sedation, respiratory depression, coma, and death. If both are prescribed, your doctor has determined the benefit outweighs significant risk. Take exactly as prescribed — never take extra doses. Do not drive or operate machinery. Seek emergency help for extreme drowsiness, slow/difficult breathing.
Excessive sedation, respiratory depression, death
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
FDA Black Box Warning. Coordinate care between prescribers.
Or browse the full interaction database (121,000+ pairs).