MAJOR — Use With Caution
DANGEROUS — FDA Black Box Warning
Evidence level: STRONG
Suboxone with Klonopin carries FDA Black Box warning.
FDA Black Box Warning: opioid + benzodiazepine.
Avoid if possible.
FDA BLACK BOX WARNING: Combining benzodiazepines with opioids can cause profound sedation, respiratory depression, coma, and death. If both are prescribed, your doctor has determined the benefit outweighs significant risk. Take exactly as prescribed — never take extra doses. Do not drive or operate machinery. Seek emergency help for extreme drowsiness, slow/difficult breathing.
High benzo doses, concurrent alcohol
Excessive sedation, respiratory depression, death
FDA Black Box Warning.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Suboxone with Klonopin carries FDA Black Box warning.
FDA BLACK BOX WARNING: Combining benzodiazepines with opioids can cause profound sedation, respiratory depression, coma, and death. If both are prescribed, your doctor has determined the benefit outweighs significant risk. Take exactly as prescribed — never take extra doses. Do not drive or operate machinery. Seek emergency help for extreme drowsiness, slow/difficult breathing.
Excessive sedation, respiratory depression, death
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
FDA Black Box Warning.
Or browse the full interaction database (121,000+ pairs).