MODERATE — Monitor Closely
🟡 MODERATE — CBD increases Alprazolam levels and adds to sedation.
Evidence level: MODERATE
CBD can increase alprazolam levels and both have calming effects. Together, you may become excessively drowsy or sedated.
CBD inhibits CYP3A4, increasing alprazolam levels. Additionally, both have CNS depressant/anxiolytic effects that are additive.
Use lower doses of both if combining. Do not drive or operate machinery until you know how the combination affects you. Start CBD at very low doses.
Take Alprazolam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. CBD Oil at a separate time. Sedating botanicals (valerian, kava, passionflower) enhance GABA activity and can amplify sedation. Use with extreme caution or avoid.
Elderly, those on other sedating medications
Excessive drowsiness, poor coordination, confusion, slowed breathing
Discuss CBD use with your prescriber, especially regarding dose adjustments
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
CBD can increase alprazolam levels and both have calming effects. Together, you may become excessively drowsy or sedated.
Take Alprazolam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. CBD Oil at a separate time. Sedating botanicals (valerian, kava, passionflower) enhance GABA activity and can amplify sedation. Use with extreme caution or avoid.
Excessive drowsiness, poor coordination, confusion, slowed breathing
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Discuss CBD use with your prescriber, especially regarding dose adjustments
Or browse the full interaction database (121,000+ pairs).