MODERATE — Monitor Closely
🟡 USE CAUTION — St. Johns Wort and Modafinil may interact. Talk to your doctor before combining.
Evidence level: LIMITED
St. John's Wort may make Provigil less effective by speeding up its breakdown.
CYP3A4 induction may reduce modafinil levels.
St. Johns Wort can affect how your body processes Modafinil. Your doctor may need to monitor drug levels or adjust doses of Modafinil while you're also taking St. Johns Wort.
Take Modafinil in the morning — stimulants should be taken early to avoid insomnia. St. Johns Wort can be taken at a separate time. Stimulating botanicals (guarana, yerba mate) amplify cardiovascular effects — use caution. Calming adaptogens (ashwagandha, lemon balm) can balance stimulant side effects when taken in the afternoon.
Higher risk with: liver impairment, genetic CYP enzyme variations (poor or ultra-rapid metabolizers), older age, polypharmacy (many medications).
Watch for signs of altered drug metabolism: either increased side effects (drug levels too high) or decreased effectiveness (drug levels too low). Report any changes to your doctor.
Mention this combination at your next appointment. Ask: "Should I adjust timing or doses of St. Johns Wort and Modafinil?" Your doctor may want to monitor specific lab values.
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
St. John's Wort may make Provigil less effective by speeding up its breakdown.
Take Modafinil in the morning — stimulants should be taken early to avoid insomnia. St. Johns Wort can be taken at a separate time. Stimulating botanicals (guarana, yerba mate) amplify cardiovascular effects — use caution. Calming adaptogens (ashwagandha, lemon balm) can balance stimulant side effects when taken in the afternoon.
Watch for signs of altered drug metabolism: either increased side effects (drug levels too high) or decreased effectiveness (drug levels too low). Report any changes to your doctor.
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
Mention this combination at your next appointment. Ask: "Should I adjust timing or doses of St. Johns Wort and Modafinil?" Your doctor may want to monitor specific lab values.
Or browse the full interaction database (121,000+ pairs).