SAFE — No Known Interaction
🟢 SAFE — St. Johns Wort and Metoprolol can be taken together safely.
Evidence level: LIMITED
St. Johns Wort and Metoprolol are safe to take together. No adverse interactions have been reported in medical literature.
No clinically significant interaction between St. Johns Wort and Metoprolol has been documented in medical literature or FDA drug labeling.
No interaction between St. Johns Wort and Metoprolol has been documented. As a best practice, keep a list of everything you take — including St. Johns Wort — and share it with your healthcare provider at every visit. This helps them spot potential issues early.
Take each at their normal times. St. Johns Wort — if it's hawthorn (a common cardiovascular botanical), it may have additive blood pressure and heart rate lowering effects with Metoprolol. Monitor pulse and blood pressure. Stimulating botanicals like ephedra (ma huang) can counteract beta-blockers.
Higher risk for: those with asthma or COPD, bradycardia, diabetes (may mask hypoglycemia symptoms), elderly, concurrent calcium channel blocker use, or peripheral vascular disease.
Monitor blood pressure and heart rate when combining St. Johns Wort with Metoprolol. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
St. Johns Wort and Metoprolol are safe to take together. No adverse interactions have been reported in medical literature.
Take each at their normal times. St. Johns Wort — if it's hawthorn (a common cardiovascular botanical), it may have additive blood pressure and heart rate lowering effects with Metoprolol. Monitor pulse and blood pressure. Stimulating botanicals like ephedra (ma huang) can counteract beta-blockers.
Monitor blood pressure and heart rate when combining St. Johns Wort with Metoprolol. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).