STOP — Contraindicated
FDA contraindication. Same risk as other amphetamine + MAO inhibitor combinations.
Evidence level: STRONG
Vyvanse (lisdexamfetamine) with rasagiline can cause a dangerous blood pressure crisis. Since Vyvanse is converted to amphetamine in your body, the same MAO inhibitor contraindication applies.
Same mechanism as amphetamine + MAO inhibitor. Lisdexamfetamine is a prodrug converted to dextroamphetamine. FDA labels contraindicate concurrent use.
Do not take Vyvanse with any MAO inhibitor including rasagiline. A 14-day washout from MAO inhibitor is required.
Take Lisdexamfetamine in the morning (or early afternoon for IR boosters) to avoid insomnia. Rasagiline follows its prescribed schedule. Acidic foods/drinks can reduce stimulant absorption — take on an empty stomach or with a non-acidic snack.
Higher risk for: those with cardiovascular conditions, hypertension, anxiety disorders, history of seizures, concurrent caffeine or sympathomimetic use, elderly, or those with hyperthyroidism.
Severe headache, chest pain, rapid heartbeat, very high blood pressure, high fever
Coordinate care between treating physicians. Discuss non-stimulant alternatives. Observe 14-day washout period.
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
Vyvanse (lisdexamfetamine) with rasagiline can cause a dangerous blood pressure crisis. Since Vyvanse is converted to amphetamine in your body, the same MAO inhibitor contraindication applies.
Take Lisdexamfetamine in the morning (or early afternoon for IR boosters) to avoid insomnia. Rasagiline follows its prescribed schedule. Acidic foods/drinks can reduce stimulant absorption — take on an empty stomach or with a non-acidic snack.
Severe headache, chest pain, rapid heartbeat, very high blood pressure, high fever
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
Coordinate care between treating physicians. Discuss non-stimulant alternatives. Observe 14-day washout period.
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