MODERATE — Monitor Closely
🟡 CAUTION — Licorice root causes pseudoaldosteronism (sodium retention, potassium wasting, blood pressure elevation) that directly opposes Telmisartan. Avoid licorice root if taking antihypertensive medications, or use DGL (deglycyrrhizinated licorice) which lacks this effect.
Evidence level: STRONG
Licorice root's glycyrrhizin compound activates mineralocorticoid receptors, causing sodium retention and potassium loss that raises blood pressure. Telmisartan blocks angiotensin II type-1 receptors to lower blood pressure and protect kidneys, but it cannot counteract the separate hormonal pathway that licorice hijacks.
Glycyrrhizin in licorice root inhibits 11-beta-hydroxysteroid dehydrogenase type 2, causing cortisol to activate mineralocorticoid receptors (pseudoaldosteronism). This causes sodium retention, potassium wasting, and blood pressure elevation — directly opposing the antihypertensive action of Telmisartan.
Avoid licorice root supplements while on Telmisartan. Telmisartan has the longest half-life among ARBs (about 24 hours) and is valued for its PPAR-gamma activity that helps with metabolic syndrome. Licorice undermines both the blood pressure and metabolic benefits. If you also take Telmisartan for diabetic kidney protection, stable blood pressure is essential — do not risk it with licorice. DGL licorice is safe.
Be consistent with how you take Telmisartan relative to meals — take it with food or without food consistently each day. Licorice Root — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Rising blood pressure despite medication, headache, swelling in legs/ankles, muscle weakness or cramps, irregular heartbeat (from low potassium).
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Licorice Root relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Licorice root's glycyrrhizin compound activates mineralocorticoid receptors, causing sodium retention and potassium loss that raises blood pressure. Telmisartan blocks angiotensin II type-1 receptors to lower blood pressure and protect kidneys, but it cannot counteract the separate hormonal pathway that licorice hijacks.
Be consistent with how you take Telmisartan relative to meals — take it with food or without food consistently each day. Licorice Root — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Rising blood pressure despite medication, headache, swelling in legs/ankles, muscle weakness or cramps, irregular heartbeat (from low potassium).
Adjust the timing or quantity of Licorice Root relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).