SAFE — No Known Interaction
🟢 SAFE — Fluoxetine and Trimethoprim-Sulfamethoxazole can be taken together safely.
Evidence level: STRONG
Fluoxetine and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
No clinically significant interaction between Fluoxetine and Trimethoprim-Sulfamethoxazole has been identified in medical literature.
No documented interaction between Fluoxetine and Trimethoprim-Sulfamethoxazole. These are commonly prescribed together without issues. Your pharmacist reviews your full medication list for interactions with every new prescription.
Take Fluoxetine and Trimethoprim-Sulfamethoxazole at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Monitor for altered effectiveness and side effects when combining Fluoxetine with Trimethoprim-Sulfamethoxazole. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Fluoxetine and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
Take Fluoxetine and Trimethoprim-Sulfamethoxazole at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Monitor for altered effectiveness and side effects when combining Fluoxetine with Trimethoprim-Sulfamethoxazole. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).