SAFE — No Known Interaction
🟢 SAFE — Apixaban and Vitamin B3 can be taken together safely.
Evidence level: MODERATE
Apixaban and Vitamin B3 are generally considered safe to use together. No adverse interactions have been reported in medical literature.
No clinically significant interaction between Apixaban and Vitamin B3 has been identified in medical literature.
No interaction documented between Apixaban and Vitamin B3. Always inform your healthcare provider about everything you take.
Critical: Vitamin K directly counteracts warfarin. If on warfarin, keep vitamin K intake CONSISTENT (don't suddenly eat more or less green vegetables). Vitamin E at high doses (>400 IU) has blood-thinning properties that amplify anticoagulant effects. Take each at their normal times but maintain dietary consistency week to week.
Higher risk for: elderly patients, those with liver disease, history of GI bleeding, concurrent use of multiple blood thinners, recent surgery, vitamin K intake changes, alcohol use, or low body weight.
Monitor for signs of altered bleeding when combining Apixaban with Vitamin B3. Watch for: unusual or easy bruising, blood in urine or stool, prolonged bleeding from minor cuts, frequent nosebleeds, bleeding gums, or heavy menstrual periods. Have your INR or clotting times checked more frequently when starting or stopping this combination. When to seek emergency help: Severe bleeding that does not stop, blood in vomit, sudden severe headache, vision changes, confusion, or weakness on one side of the body (possible internal bleeding or stroke).
No urgent discussion needed, but keep your provider informed. Say: "I take Apixaban alongside Vitamin B3 — anything I should know?"
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
Apixaban and Vitamin B3 are generally considered safe to use together. No adverse interactions have been reported in medical literature.
Critical: Vitamin K directly counteracts warfarin. If on warfarin, keep vitamin K intake CONSISTENT (don't suddenly eat more or less green vegetables). Vitamin E at high doses (>400 IU) has blood-thinning properties that amplify anticoagulant effects. Take each at their normal times but maintain dietary consistency week to week.
Monitor for signs of altered bleeding when combining Apixaban with Vitamin B3. Watch for: unusual or easy bruising, blood in urine or stool, prolonged bleeding from minor cuts, frequent nosebleeds, bleeding gums, or heavy menstrual periods. Have your INR or clotting times checked more frequently when starting or stopping this combination. When to seek emergency help: Severe bleeding that does not stop, blood in vomit, sudden severe headache, vision changes, confusion, or weakness on one side of the body (possible internal bleeding or stroke).
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
No urgent discussion needed, but keep your provider informed. Say: "I take Apixaban alongside Vitamin B3 — anything I should know?"
Or browse the full interaction database (121,000+ pairs).