SAFE — No Known Interaction
🟢 SAFE — Apixaban and Feverfew can be taken together safely.
Evidence level: LIMITED
Apixaban and Feverfew are generally considered safe to use together. No adverse interactions have been reported in medical literature.
No clinically significant interaction between Apixaban and Feverfew has been identified in medical literature.
No interaction documented between Apixaban and Feverfew. Always inform your healthcare provider about everything you take.
Use caution. Many botanicals affect blood clotting — ginkgo, garlic, ginger, turmeric, and dong quai all have antiplatelet activity that can amplify Apixaban. St. John's Wort can REDUCE anticoagulant effectiveness. Take at separate times and inform your prescriber about all herbal supplements. Request more frequent INR monitoring if on warfarin.
Higher risk for: elderly patients, those with liver disease, history of GI bleeding, concurrent use of multiple blood thinners, recent surgery, vitamin K intake changes, alcohol use, or low body weight.
Monitor for signs of altered bleeding when combining Apixaban with Feverfew. Watch for: unusual or easy bruising, blood in urine or stool, prolonged bleeding from minor cuts, frequent nosebleeds, bleeding gums, or heavy menstrual periods. Have your INR or clotting times checked more frequently when starting or stopping this combination. When to seek emergency help: Severe bleeding that does not stop, blood in vomit, sudden severe headache, vision changes, confusion, or weakness on one side of the body (possible internal bleeding or stroke).
No urgent discussion needed, but keep your provider informed. Say: "I take Apixaban alongside Feverfew — anything I should know?"
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
Apixaban and Feverfew are generally considered safe to use together. No adverse interactions have been reported in medical literature.
Use caution. Many botanicals affect blood clotting — ginkgo, garlic, ginger, turmeric, and dong quai all have antiplatelet activity that can amplify Apixaban. St. John's Wort can REDUCE anticoagulant effectiveness. Take at separate times and inform your prescriber about all herbal supplements. Request more frequent INR monitoring if on warfarin.
Monitor for signs of altered bleeding when combining Apixaban with Feverfew. Watch for: unusual or easy bruising, blood in urine or stool, prolonged bleeding from minor cuts, frequent nosebleeds, bleeding gums, or heavy menstrual periods. Have your INR or clotting times checked more frequently when starting or stopping this combination. When to seek emergency help: Severe bleeding that does not stop, blood in vomit, sudden severe headache, vision changes, confusion, or weakness on one side of the body (possible internal bleeding or stroke).
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
No urgent discussion needed, but keep your provider informed. Say: "I take Apixaban alongside Feverfew — anything I should know?"
Or browse the full interaction database (121,000+ pairs).