SAFE — No Known Interaction
🟢 SAFE — Clarithromycin and Amoxicillin/Clavulanate can be taken together safely.
Evidence level: MODERATE
Clarithromycin and Amoxicillin/Clavulanate are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
No clinically significant interaction between Clarithromycin and Amoxicillin/Clavulanate has been identified in medical literature or FDA drug labeling.
Complete your full course of Clarithromycin as prescribed alongside Amoxicillin/Clavulanate. Some antibiotics can temporarily alter how other drugs are metabolized. If you experience unusual side effects during the antibiotic course, contact your prescriber.
Taking two antibiotics simultaneously is common in certain infections (TB, H. pylori, resistant UTIs). Follow each antibiotic's specific food instructions carefully — some require empty stomach (e.g., tetracyclines), others need food (e.g., amoxicillin/clavulanate). Complete both full courses even if symptoms resolve early.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Monitor for altered effectiveness and side effects when combining Clarithromycin with Amoxicillin/Clavulanate. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Clarithromycin and Amoxicillin/Clavulanate — is that OK?"
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Clarithromycin and Amoxicillin/Clavulanate are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
Taking two antibiotics simultaneously is common in certain infections (TB, H. pylori, resistant UTIs). Follow each antibiotic's specific food instructions carefully — some require empty stomach (e.g., tetracyclines), others need food (e.g., amoxicillin/clavulanate). Complete both full courses even if symptoms resolve early.
Monitor for altered effectiveness and side effects when combining Clarithromycin with Amoxicillin/Clavulanate. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Clarithromycin and Amoxicillin/Clavulanate — is that OK?"
Or browse the full interaction database (121,000+ pairs).