STOP — Contraindicated
FDA contraindication. Risk of hypertensive crisis, hyperthermia, seizures. Do not co-administer.
Evidence level: STRONG
Adderall combined with rasagiline (a Parkinson drug that inhibits MAO) can cause a hypertensive crisis — a sudden, dangerous spike in blood pressure. Both drugs increase brain chemicals in ways that become dangerous together.
Amphetamines increase monoamine release. Rasagiline (MAO-B inhibitor) prevents monoamine breakdown. Combined effect can cause hypertensive crisis and hyperthermia. FDA labels contraindicate this.
Do not take stimulant medications with MAO inhibitors. If you have both ADHD and Parkinson disease, your doctors must coordinate to find safe alternatives.
Take Amphetamine/Dextroamphetamine in the morning (or early afternoon for IR boosters) to avoid insomnia. Rasagiline follows its prescribed schedule. Acidic foods/drinks can reduce stimulant absorption — take on an empty stomach or with a non-acidic snack.
Higher risk for: those with cardiovascular conditions, hypertension, anxiety disorders, history of seizures, concurrent caffeine or sympathomimetic use, elderly, or those with hyperthyroidism.
Severe headache, rapid heartbeat, chest pain, neck stiffness, nausea, sweating, dilated pupils, very high blood pressure
Coordinate between neurologist and psychiatrist. Discuss non-stimulant ADHD options (atomoxetine may also be problematic — it is a norepinephrine reuptake inhibitor). Consider behavioral interventions.
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
Adderall combined with rasagiline (a Parkinson drug that inhibits MAO) can cause a hypertensive crisis — a sudden, dangerous spike in blood pressure. Both drugs increase brain chemicals in ways that become dangerous together.
Take Amphetamine/Dextroamphetamine in the morning (or early afternoon for IR boosters) to avoid insomnia. Rasagiline follows its prescribed schedule. Acidic foods/drinks can reduce stimulant absorption — take on an empty stomach or with a non-acidic snack.
Severe headache, rapid heartbeat, chest pain, neck stiffness, nausea, sweating, dilated pupils, very high blood pressure
Stimulant combinations can increase cardiovascular strain. Reduce caffeine intake and avoid other stimulating supplements. Discuss with your prescriber: non-stimulant ADHD options (atomoxetine, guanfacine) or L-theanine for focus without the sympathomimetic load.
Coordinate between neurologist and psychiatrist. Discuss non-stimulant ADHD options (atomoxetine may also be problematic — it is a norepinephrine reuptake inhibitor). Consider behavioral interventions.
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