STOP — Contraindicated
FDA contraindication on ziprasidone label. Use alternative antipsychotic or alternative antiarrhythmic.
Evidence level: STRONG
Both ziprasidone (Geodon) and sotalol prolong the QT interval. The FDA says these should not be used together because of the high risk of dangerous heart rhythm problems.
Both drugs prolong QT interval. Ziprasidone label contraindicates concurrent use with QT-prolonging drugs. Sotalol is a Class III antiarrhythmic that prolongs QT as part of its mechanism.
Do not take these together. Your doctors should coordinate to find safer alternatives for either the psychiatric or heart condition.
Take Sotalol at the same time daily — never stop abruptly (risk of rebound hypertension). Ziprasidone follows its prescribed schedule. Beta-blockers can be taken with or without food.
Higher risk for: those with asthma or COPD, bradycardia, diabetes (may mask hypoglycemia symptoms), elderly, concurrent calcium channel blocker use, or peripheral vascular disease.
Fainting, palpitations, irregular heartbeat, dizziness, sudden collapse
Switch to antipsychotic with lower QT risk. If sotalol is needed for rate/rhythm control, avoid QT-prolonging antipsychotics.
Beta blocker interactions can affect heart rate and blood pressure. Discuss with your doctor: alternative blood pressure medications (ACE inhibitors, ARBs) may have fewer interactions. Monitor heart rate and report any dizziness or fatigue.
Both ziprasidone (Geodon) and sotalol prolong the QT interval. The FDA says these should not be used together because of the high risk of dangerous heart rhythm problems.
Take Sotalol at the same time daily — never stop abruptly (risk of rebound hypertension). Ziprasidone follows its prescribed schedule. Beta-blockers can be taken with or without food.
Fainting, palpitations, irregular heartbeat, dizziness, sudden collapse
Beta blocker interactions can affect heart rate and blood pressure. Discuss with your doctor: alternative blood pressure medications (ACE inhibitors, ARBs) may have fewer interactions. Monitor heart rate and report any dizziness or fatigue.
Switch to antipsychotic with lower QT risk. If sotalol is needed for rate/rhythm control, avoid QT-prolonging antipsychotics.
Or browse the full interaction database (121,000+ pairs).