STOP — Contraindicated
FDA contraindication — do not use together. 14-day washout after stopping selegiline before starting SSRI (and vice versa).
Evidence level: STRONG
Selegiline (Eldepryl, Emsam) and sertraline (Zoloft) must not be used together. Selegiline is an MAO inhibitor used for Parkinson disease, and combining it with an SSRI can cause dangerous serotonin syndrome.
Selegiline is an irreversible MAO-B inhibitor (at recommended doses). Combined with SSRI serotonin reuptake inhibition, severe serotonin syndrome risk. FDA labels for both drugs warn against this combination.
A 14-day washout period is required when switching between these medications. Tell all your doctors about every medication you take.
Take Sertraline at the same time each day — morning is most common to avoid sleep disruption. Selegiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
High fever, muscle rigidity, rapid heart rate, blood pressure instability, agitation, confusion, seizures
Discuss 14-day washout protocol. Ask about depression treatment options compatible with MAO inhibitor therapy.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Selegiline (Eldepryl, Emsam) and sertraline (Zoloft) must not be used together. Selegiline is an MAO inhibitor used for Parkinson disease, and combining it with an SSRI can cause dangerous serotonin syndrome.
Take Sertraline at the same time each day — morning is most common to avoid sleep disruption. Selegiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
High fever, muscle rigidity, rapid heart rate, blood pressure instability, agitation, confusion, seizures
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Discuss 14-day washout protocol. Ask about depression treatment options compatible with MAO inhibitor therapy.
Or browse the full interaction database (121,000+ pairs).