SAFE — No Known Interaction
🟢 SAFE — Rosuvastatin and Trimethoprim-Sulfamethoxazole can be taken together safely.
Evidence level: STRONG
Rosuvastatin and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
No clinically significant interaction between Rosuvastatin and Trimethoprim-Sulfamethoxazole has been identified in medical literature.
No documented interaction between Rosuvastatin and Trimethoprim-Sulfamethoxazole. These are commonly prescribed together without issues. Your pharmacist reviews your full medication list for interactions with every new prescription.
Some antibiotics (erythromycin, clarithromycin) strongly inhibit CYP3A4 and can dramatically increase statin levels, raising rhabdomyolysis risk. Take Rosuvastatin in the evening as usual. Your prescriber may temporarily pause or reduce the statin during short antibiotic courses.
Higher risk for: those with liver impairment, genetic CYP enzyme variations (poor or ultra-rapid metabolizers), elderly, those on multiple CYP3A4 inhibitors, high-dose statin therapy, or history of myopathy.
Monitor for muscle and liver effects when combining Rosuvastatin with Trimethoprim-Sulfamethoxazole. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Rosuvastatin and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
Some antibiotics (erythromycin, clarithromycin) strongly inhibit CYP3A4 and can dramatically increase statin levels, raising rhabdomyolysis risk. Take Rosuvastatin in the evening as usual. Your prescriber may temporarily pause or reduce the statin during short antibiotic courses.
Monitor for muscle and liver effects when combining Rosuvastatin with Trimethoprim-Sulfamethoxazole. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).