SAFE — No Known Interaction
🟢 SAFE — Rosuvastatin and Penicillin V can be taken together safely.
Evidence level: STRONG
Rosuvastatin and Penicillin V are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
No clinically significant interaction between Rosuvastatin and Penicillin V has been identified in medical literature or FDA drug labeling.
Complete your full course of Penicillin V as prescribed alongside Rosuvastatin. Some antibiotics can temporarily alter how other drugs are metabolized. If you experience unusual side effects during the antibiotic course, contact your prescriber.
Some antibiotics (erythromycin, clarithromycin) strongly inhibit CYP3A4 and can dramatically increase statin levels, raising rhabdomyolysis risk. Take Rosuvastatin in the evening as usual. Your prescriber may temporarily pause or reduce the statin during short antibiotic courses.
Higher risk for: those with liver impairment, genetic CYP enzyme variations (poor or ultra-rapid metabolizers), elderly, those on multiple CYP3A4 inhibitors, high-dose statin therapy, or history of myopathy.
Monitor for muscle and liver effects when combining Rosuvastatin with Penicillin V. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Rosuvastatin and Penicillin V — is that OK?"
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Rosuvastatin and Penicillin V are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
Some antibiotics (erythromycin, clarithromycin) strongly inhibit CYP3A4 and can dramatically increase statin levels, raising rhabdomyolysis risk. Take Rosuvastatin in the evening as usual. Your prescriber may temporarily pause or reduce the statin during short antibiotic courses.
Monitor for muscle and liver effects when combining Rosuvastatin with Penicillin V. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Rosuvastatin and Penicillin V — is that OK?"
Or browse the full interaction database (121,000+ pairs).