SAFE — No Known Interaction
🟢 SAFE — Modafinil and Yerba Mate can be taken together safely.
Evidence level: MODERATE
Modafinil and Yerba Mate are generally safe to use together. No adverse interactions have been reported.
No clinically significant interaction between Modafinil and Yerba Mate has been documented in medical literature.
No dietary interaction between Modafinil and Yerba Mate. You can consume both without concern.
Take Modafinil in the morning. Acidic foods and drinks (orange juice, vitamin C-rich fruits, sodas) can reduce amphetamine absorption — avoid within 1 hour. Yerba Mate — protein-rich meals may help sustain stimulant effects longer.
Higher risk for: those with cardiovascular conditions, hypertension, anxiety disorders, history of seizures, concurrent caffeine or sympathomimetic use, elderly, or those with hyperthyroidism.
Monitor heart rate and blood pressure when combining Modafinil with Yerba Mate. Watch for: jitteriness, insomnia, heart palpitations, anxiety, excessive sweating, restlessness, or appetite loss. Some natural products can amplify stimulant effects. When to seek emergency help: Chest pain, irregular heartbeat, severe anxiety or panic, difficulty breathing, or fainting. Reduce caffeine intake while using stimulant medications. Tell your prescriber about all supplements you take.
No urgent discussion needed. Keep your provider informed of your full supplement list.
Safe combination. No dietary restrictions needed. Maintaining a consistent diet helps ensure predictable supplement and medication performance.
Modafinil and Yerba Mate are generally safe to use together. No adverse interactions have been reported.
Take Modafinil in the morning. Acidic foods and drinks (orange juice, vitamin C-rich fruits, sodas) can reduce amphetamine absorption — avoid within 1 hour. Yerba Mate — protein-rich meals may help sustain stimulant effects longer.
Monitor heart rate and blood pressure when combining Modafinil with Yerba Mate. Watch for: jitteriness, insomnia, heart palpitations, anxiety, excessive sweating, restlessness, or appetite loss. Some natural products can amplify stimulant effects. When to seek emergency help: Chest pain, irregular heartbeat, severe anxiety or panic, difficulty breathing, or fainting. Reduce caffeine intake while using stimulant medications. Tell your prescriber about all supplements you take.
Safe combination. No dietary restrictions needed. Maintaining a consistent diet helps ensure predictable supplement and medication performance.
No urgent discussion needed. Keep your provider informed of your full supplement list.
Or browse the full interaction database (121,000+ pairs).