Lisinopril + Rifaximin

SAFE — No Known Interaction

🟢 SAFE — Lisinopril and Rifaximin can be taken together safely.

Evidence level: MODERATE

What this interaction means

Lisinopril and Rifaximin are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

How it works (mechanism)

No clinically significant interaction between Lisinopril and Rifaximin has been identified in medical literature or FDA drug labeling.

Practical advice

Complete your full course of Rifaximin as prescribed alongside Lisinopril. Some antibiotics can temporarily alter how other drugs are metabolized. If you experience unusual side effects during the antibiotic course, contact your prescriber.

Timing

Follow each medication's specific timing instructions. Rifaximin — check if it requires an empty stomach or should be taken with food. Lisinopril follows its normal schedule. Complete the full antibiotic course as prescribed.

Risk factors

Higher risk for: those with renal impairment, hyperkalemia risk, concurrent potassium-sparing diuretics or potassium supplements, elderly, dehydrated patients, or those with bilateral renal artery stenosis.

Symptoms to watch for

Monitor blood pressure and heart rate when combining Lisinopril with Rifaximin. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

What to tell your doctor

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Rifaximin — is that OK?"

Safer alternatives

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

Frequently asked questions

Can I take Lisinopril and Rifaximin together?

Lisinopril and Rifaximin are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

When should I take Lisinopril vs Rifaximin?

Follow each medication's specific timing instructions. Rifaximin — check if it requires an empty stomach or should be taken with food. Lisinopril follows its normal schedule. Complete the full antibiotic course as prescribed.

What symptoms should I watch for if I combine Lisinopril and Rifaximin?

Monitor blood pressure and heart rate when combining Lisinopril with Rifaximin. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

Are there safer alternatives to combining Lisinopril with Rifaximin?

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

What should I tell my doctor about taking Lisinopril and Rifaximin?

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Rifaximin — is that OK?"

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