Lisinopril + Naloxone

SAFE — No Known Interaction

🟢 SAFE — Lisinopril and Naloxone can be taken together safely.

Evidence level: MODERATE

What this interaction means

Lisinopril and Naloxone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

How it works (mechanism)

No clinically significant interaction between Lisinopril and Naloxone has been identified in medical literature or FDA drug labeling.

Practical advice

Lisinopril and Naloxone are compatible. Monitor blood pressure regularly. Report persistent dry cough, swelling of face/lips, or elevated potassium symptoms (muscle weakness, irregular heartbeat) to your prescriber.

Timing

Take Lisinopril at the same time daily. Naloxone follows its prescribed schedule. ACE inhibitors can be taken with or without food. If you develop a persistent dry cough, report it to your prescriber.

Risk factors

Higher risk for: those with renal impairment, hyperkalemia risk, concurrent potassium-sparing diuretics or potassium supplements, elderly, dehydrated patients, or those with bilateral renal artery stenosis.

Symptoms to watch for

Monitor blood pressure and heart rate when combining Lisinopril with Naloxone. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

What to tell your doctor

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Naloxone — is that OK?"

Safer alternatives

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

Frequently asked questions

Can I take Lisinopril and Naloxone together?

Lisinopril and Naloxone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

When should I take Lisinopril vs Naloxone?

Take Lisinopril at the same time daily. Naloxone follows its prescribed schedule. ACE inhibitors can be taken with or without food. If you develop a persistent dry cough, report it to your prescriber.

What symptoms should I watch for if I combine Lisinopril and Naloxone?

Monitor blood pressure and heart rate when combining Lisinopril with Naloxone. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

Are there safer alternatives to combining Lisinopril with Naloxone?

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

What should I tell my doctor about taking Lisinopril and Naloxone?

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Naloxone — is that OK?"

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