SAFE — No Known Interaction
🟢 SAFE — Levothyroxine and Methotrexate can be taken together safely.
Evidence level: MODERATE
Levothyroxine and Methotrexate are safe to take together based on current evidence. No adverse interactions reported.
No clinically significant interaction between Levothyroxine and Methotrexate has been identified in medical literature.
No documented interaction between Levothyroxine and Methotrexate. These are commonly prescribed together without issues. Your pharmacist reviews your full medication list for interactions with every new prescription.
Take levothyroxine first thing in the morning on an empty stomach, 30-60 minutes before food. Take all other supplements and medications at least 4 hours later.
Higher risk for: elderly with cardiac conditions, those with adrenal insufficiency, recent thyroid dose adjustments, concurrent calcium/iron/antacid use (absorption interference), or narrow therapeutic index sensitivity.
Monitor thyroid function when combining Levothyroxine with Methotrexate. Some medications can alter thyroid hormone levels or metabolism. Watch for hypo symptoms (fatigue, weight gain, cold sensitivity, constipation) or hyper symptoms (anxiety, rapid pulse, weight loss, tremors, heat intolerance). Get thyroid levels (TSH, free T4) rechecked 6-8 weeks after starting or stopping the combination. When to seek emergency help: Chest pain, rapid or irregular heartbeat, high fever with confusion, or severe swelling of the neck.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Levothyroxine and Methotrexate are safe to take together based on current evidence. No adverse interactions reported.
Take levothyroxine first thing in the morning on an empty stomach, 30-60 minutes before food. Take all other supplements and medications at least 4 hours later.
Monitor thyroid function when combining Levothyroxine with Methotrexate. Some medications can alter thyroid hormone levels or metabolism. Watch for hypo symptoms (fatigue, weight gain, cold sensitivity, constipation) or hyper symptoms (anxiety, rapid pulse, weight loss, tremors, heat intolerance). Get thyroid levels (TSH, free T4) rechecked 6-8 weeks after starting or stopping the combination. When to seek emergency help: Chest pain, rapid or irregular heartbeat, high fever with confusion, or severe swelling of the neck.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).