MODERATE — Monitor Closely
🟡 CAUTION — Grapefruit inhibits CYP3A4, potentially increasing quetiapine levels and sedation. Avoid regular grapefruit consumption.
Evidence level: MODERATE
Grapefruit may increase quetiapine levels, causing more sedation and potentially other side effects.
Grapefruit inhibits CYP3A4, the primary enzyme metabolizing quetiapine, potentially increasing quetiapine levels and sedation.
Avoid or limit grapefruit while taking quetiapine. Watch for increased drowsiness.
Be consistent with how you take Quetiapine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Excessive sedation, dizziness, orthostatic hypotension, dry mouth.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit may increase quetiapine levels, causing more sedation and potentially other side effects.
Be consistent with how you take Quetiapine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Excessive sedation, dizziness, orthostatic hypotension, dry mouth.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).