MODERATE — Monitor Closely
🟡 CAUTION — Grapefruit inhibits CYP3A4, increasing nifedipine bioavailability and enhancing hypotensive effects. Avoid grapefruit while taking nifedipine.
Evidence level: STRONG
Grapefruit can increase nifedipine levels, potentially causing your blood pressure to drop too low.
Grapefruit inhibits CYP3A4, increasing nifedipine bioavailability and enhancing hypotensive effects.
Avoid grapefruit while taking nifedipine. The combination can cause dangerous drops in blood pressure.
Be consistent with how you take Nifedipine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Dizziness, lightheadedness, fainting, flushing, rapid heartbeat, headache.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit can increase nifedipine levels, potentially causing your blood pressure to drop too low.
Be consistent with how you take Nifedipine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Dizziness, lightheadedness, fainting, flushing, rapid heartbeat, headache.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).