Enalapril + Vilazodone

SAFE — No Known Interaction

🟢 SAFE — Enalapril and Vilazodone can be taken together safely.

Evidence level: STRONG

What this interaction means

Enalapril and Vilazodone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

How it works (mechanism)

No clinically significant interaction between Enalapril and Vilazodone has been identified in medical literature or FDA drug labeling.

Practical advice

Enalapril and Vilazodone are compatible. Monitor blood pressure regularly. Report persistent dry cough, swelling of face/lips, or elevated potassium symptoms (muscle weakness, irregular heartbeat) to your prescriber.

Timing

No significant timing interaction. Take each at their prescribed times. There may be additive hypotension risk — stand up slowly from sitting or lying positions. Some patients on this combination report slightly more dizziness.

Risk factors

Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.

Symptoms to watch for

Monitor blood pressure and heart rate when combining Enalapril with Vilazodone. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

What to tell your doctor

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Enalapril and Vilazodone — is that OK?"

Safer alternatives

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

Frequently asked questions

Can I take Enalapril and Vilazodone together?

Enalapril and Vilazodone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.

When should I take Enalapril vs Vilazodone?

No significant timing interaction. Take each at their prescribed times. There may be additive hypotension risk — stand up slowly from sitting or lying positions. Some patients on this combination report slightly more dizziness.

What symptoms should I watch for if I combine Enalapril and Vilazodone?

Monitor blood pressure and heart rate when combining Enalapril with Vilazodone. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

Are there safer alternatives to combining Enalapril with Vilazodone?

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

What should I tell my doctor about taking Enalapril and Vilazodone?

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Enalapril and Vilazodone — is that OK?"

Explore more interactions

Or browse the full interaction database (121,000+ pairs).