SAFE — No Known Interaction
🟢 SAFE — Lisinopril and Donepezil can be taken together safely.
Evidence level: MODERATE
Lisinopril and Donepezil are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
No clinically significant interaction between Lisinopril and Donepezil has been identified in medical literature or FDA drug labeling.
Lisinopril and Donepezil are compatible. Monitor blood pressure regularly. Report persistent dry cough, swelling of face/lips, or elevated potassium symptoms (muscle weakness, irregular heartbeat) to your prescriber.
Take Lisinopril at the same time daily. Donepezil follows its prescribed schedule. ACE inhibitors can be taken with or without food. If you develop a persistent dry cough, report it to your prescriber.
Higher risk for: those with renal impairment, hyperkalemia risk, concurrent potassium-sparing diuretics or potassium supplements, elderly, dehydrated patients, or those with bilateral renal artery stenosis.
Monitor blood pressure and heart rate when combining Lisinopril with Donepezil. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Donepezil — is that OK?"
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Lisinopril and Donepezil are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
Take Lisinopril at the same time daily. Donepezil follows its prescribed schedule. ACE inhibitors can be taken with or without food. If you develop a persistent dry cough, report it to your prescriber.
Monitor blood pressure and heart rate when combining Lisinopril with Donepezil. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take Lisinopril and Donepezil — is that OK?"
Or browse the full interaction database (121,000+ pairs).