MODERATE — Monitor Closely
🟡 CAUTION — Grapefruit inhibits CYP3A4, increasing diltiazem levels and enhancing cardiovascular effects. Avoid grapefruit while taking diltiazem.
Evidence level: MODERATE
Grapefruit can increase diltiazem levels, potentially causing excessive blood pressure lowering and heart rate slowing.
Grapefruit inhibits CYP3A4, increasing diltiazem levels and enhancing its cardiovascular effects.
Limit or avoid grapefruit while taking diltiazem. Monitor blood pressure and heart rate.
Be consistent with how you take Diltiazem relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Dizziness, slow heartbeat, lightheadedness, fainting, ankle swelling.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit can increase diltiazem levels, potentially causing excessive blood pressure lowering and heart rate slowing.
Be consistent with how you take Diltiazem relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Dizziness, slow heartbeat, lightheadedness, fainting, ankle swelling.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).