SAFE — No Known Interaction
🟢 SAFE — Cyclobenzaprine and Trimethoprim-Sulfamethoxazole can be taken together safely.
Evidence level: MODERATE
Cyclobenzaprine and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
No clinically significant interaction between Cyclobenzaprine and Trimethoprim-Sulfamethoxazole has been identified in medical literature.
No documented interaction between Cyclobenzaprine and Trimethoprim-Sulfamethoxazole. These are commonly prescribed together without issues. Your pharmacist reviews your full medication list for interactions with every new prescription.
Follow each medication's specific timing instructions. Trimethoprim-Sulfamethoxazole — check if it requires an empty stomach or should be taken with food. Cyclobenzaprine follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Monitor for altered effectiveness and side effects when combining Cyclobenzaprine with Trimethoprim-Sulfamethoxazole. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
Cyclobenzaprine and Trimethoprim-Sulfamethoxazole are safe to take together based on current evidence. No adverse interactions reported.
Follow each medication's specific timing instructions. Trimethoprim-Sulfamethoxazole — check if it requires an empty stomach or should be taken with food. Cyclobenzaprine follows its normal schedule. Complete the full antibiotic course as prescribed.
Monitor for altered effectiveness and side effects when combining Cyclobenzaprine with Trimethoprim-Sulfamethoxazole. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).