MODERATE — Monitor Closely
🟡 MODERATE — Avoid grapefruit with Cyclobenzaprine.
Evidence level: LIMITED
Grapefruit may increase cyclobenzaprine levels, causing more drowsiness than expected.
Grapefruit inhibits CYP3A4, potentially increasing cyclobenzaprine levels and enhancing sedation.
Avoid grapefruit while taking cyclobenzaprine. Be cautious with activities requiring alertness.
Be consistent with how you take Cyclobenzaprine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Elderly, those on other CNS depressants
Excessive drowsiness, dry mouth, dizziness
Mention grapefruit use if experiencing excessive side effects
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit may increase cyclobenzaprine levels, causing more drowsiness than expected.
Be consistent with how you take Cyclobenzaprine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Excessive drowsiness, dry mouth, dizziness
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Mention grapefruit use if experiencing excessive side effects
Or browse the full interaction database (121,000+ pairs).