MAJOR — Use With Caution
🔴 AVOID — Colchicine has a narrow therapeutic index. Grapefruit inhibits CYP3A4 and P-glycoprotein, elevating colchicine levels and risking severe multi-organ toxicity.
Evidence level: STRONG
Grapefruit increases colchicine levels significantly. Colchicine toxicity can be fatal — it affects your bone marrow, muscles, and organs.
Grapefruit inhibits CYP3A4 and P-glycoprotein, both involved in colchicine metabolism. Colchicine has a narrow therapeutic index — elevated levels cause severe toxicity including multi-organ failure.
Avoid grapefruit entirely while taking colchicine. Colchicine toxicity has no specific antidote and can be fatal.
Be consistent with how you take Colchicine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Severe nausea, vomiting, diarrhea, abdominal pain, muscle weakness, burning throat. Seek emergency care immediately.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit increases colchicine levels significantly. Colchicine toxicity can be fatal — it affects your bone marrow, muscles, and organs.
Be consistent with how you take Colchicine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Severe nausea, vomiting, diarrhea, abdominal pain, muscle weakness, burning throat. Seek emergency care immediately.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).