STOP — Contraindicated
FDA Black Box Warning — avoid concurrent use.
Evidence level: STRONG
Combining hydrocodone with clonazepam is life-threatening. Both drugs slow breathing and brain activity. The FDA Black Box Warning exists because this combination kills people every year.
Combined CNS depression: opioid mu-receptor agonism plus GABA-A receptor potentiation. FDA Black Box Warning.
Do not take together without doctor supervision. If prescribed both, ask about alternatives for one medication.
Take Clonazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Hydrocodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Higher risk for: elderly, opioid-naive patients, those with sleep apnea, respiratory conditions, concurrent CNS depressants (benzodiazepines, alcohol), liver impairment, or history of substance use disorder.
Extreme sedation, slow or stopped breathing, bluish lips, unresponsiveness
Ask your doctor: Is there a non-opioid pain medication or a non-benzodiazepine that could replace one of these?
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Combining hydrocodone with clonazepam is life-threatening. Both drugs slow breathing and brain activity. The FDA Black Box Warning exists because this combination kills people every year.
Take Clonazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Hydrocodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Extreme sedation, slow or stopped breathing, bluish lips, unresponsiveness
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Ask your doctor: Is there a non-opioid pain medication or a non-benzodiazepine that could replace one of these?
Or browse the full interaction database (121,000+ pairs).