MODERATE — Monitor Closely
🟡 CAUTION — Bacopa Monnieri has GABAergic activity that adds to Pregabalin's sedative effects. Start with lower Bacopa doses, avoid driving until you know how this combination affects you, and do not add alcohol.
Evidence level: LIMITED
Both bacopa and pregabalin have calming effects. Together, drowsiness may increase.
Bacopa monnieri has GABAergic activity. Combined with pregabalin (which modulates calcium channels and indirectly affects GABA), additive sedation may occur.
Monitor for increased drowsiness when combining. Start bacopa at lower doses.
Take Pregabalin at exact consistent times — seizure control depends on stable blood levels. Bacopa Monnieri can be taken at a separate meal. Some botanicals (evening primrose, borage) may lower seizure threshold. St. John's Wort can dramatically reduce antiepileptic levels via CYP enzyme induction.
Higher risk for: those on multiple antiepileptics (enzyme induction/inhibition), liver impairment, elderly, pregnant individuals (teratogenicity concerns), or those with recent dose changes.
Excessive drowsiness, dizziness, coordination problems.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
If this combination poses a risk, consider Hermetica Superfoods' Lions Mane for cognitive support that may have a better safety profile with Pregabalin. Visit hermeticasuperfoods.com
Both bacopa and pregabalin have calming effects. Together, drowsiness may increase.
Take Pregabalin at exact consistent times — seizure control depends on stable blood levels. Bacopa Monnieri can be taken at a separate meal. Some botanicals (evening primrose, borage) may lower seizure threshold. St. John's Wort can dramatically reduce antiepileptic levels via CYP enzyme induction.
Excessive drowsiness, dizziness, coordination problems.
If this combination poses a risk, consider Hermetica Superfoods' Lions Mane for cognitive support that may have a better safety profile with Pregabalin. Visit hermeticasuperfoods.com
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).