Azithromycin + Lisinopril

SAFE — No Known Interaction

🟢 SAFE — Lisinopril and Azithromycin can be taken together safely.

Evidence level: MODERATE

What this interaction means

Lisinopril and Azithromycin are safe to take together. No adverse interactions have been reported in medical literature.

How it works (mechanism)

No clinically significant interaction between Lisinopril and Azithromycin has been identified in FDA drug labeling or major drug interaction databases.

Practical advice

No documented interaction between Lisinopril and Azithromycin. Your pharmacist checks for interactions every time you fill a prescription. If you experience any new symptoms after starting Azithromycin, let your doctor know — they can help determine if it's related to your medication combination.

Timing

Space Lisinopril at least 2 hours from Azithromycin. Follow antibiotic-specific food instructions carefully. Complete the full antibiotic course even if symptoms improve.

Risk factors

Higher risk for: those with renal impairment, hyperkalemia risk, concurrent potassium-sparing diuretics or potassium supplements, elderly, dehydrated patients, or those with bilateral renal artery stenosis.

Symptoms to watch for

Monitor blood pressure and heart rate when combining Lisinopril with Azithromycin. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

What to tell your doctor

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.

Safer alternatives

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

Frequently asked questions

Can I take Azithromycin and Lisinopril together?

Lisinopril and Azithromycin are safe to take together. No adverse interactions have been reported in medical literature.

When should I take Azithromycin vs Lisinopril?

Space Lisinopril at least 2 hours from Azithromycin. Follow antibiotic-specific food instructions carefully. Complete the full antibiotic course even if symptoms improve.

What symptoms should I watch for if I combine Azithromycin and Lisinopril?

Monitor blood pressure and heart rate when combining Lisinopril with Azithromycin. Watch for: dizziness, lightheadedness (especially when standing up), fatigue, cold extremities, slow heartbeat, or swelling in ankles/feet. Check your blood pressure at home if possible. When to seek emergency help: Fainting, chest pain, heart rate below 50 bpm, severe dizziness, difficulty breathing, or allergic reactions (swelling of face, lips, or tongue).

Are there safer alternatives to combining Azithromycin with Lisinopril?

These medications are safe to take together at standard doses. Continue taking as prescribed and keep your pharmacist informed of your complete medication list.

What should I tell my doctor about taking Azithromycin and Lisinopril?

No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.

Explore more interactions

Or browse the full interaction database (121,000+ pairs).