SAFE — No Known Interaction
🟢 SAFE — Ashwagandha and Pravastatin can be taken together safely.
Evidence level: LIMITED
Ashwagandha and Pravastatin are safe to use together. Pravastatin is notable among statins because it is not metabolized by the CYP450 enzyme system, making it one of the least interaction-prone statins available. This means ashwagandha's mild effects on liver enzymes are completely irrelevant when paired with Pravastatin.
No clinically significant interaction between Ashwagandha and Pravastatin has been documented in medical literature or FDA drug labeling.
Pravastatin is best taken at bedtime for peak effectiveness, while ashwagandha works well at any time. Since Pravastatin bypasses liver CYP enzymes entirely (it's cleared by the kidneys and sulfation), there is essentially zero pharmacokinetic interaction risk with any herbal supplement. Standard ashwagandha dosing (300-600mg) is perfectly fine alongside Pravastatin.
Take Pravastatin in the evening when hepatic cholesterol synthesis peaks (exception: atorvastatin and rosuvastatin have long half-lives and can be taken any time). Ashwagandha can be taken at a separate meal. Avoid St. John's Wort (reduces statin levels via CYP3A4 induction) and grapefruit extract (increases levels). Report any unexplained muscle pain or weakness.
Higher risk for: those with liver impairment, genetic CYP enzyme variations (poor or ultra-rapid metabolizers), elderly, those on multiple CYP3A4 inhibitors, high-dose statin therapy, or history of myopathy.
Monitor for muscle and liver effects when combining Ashwagandha with Pravastatin. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
This is a safe combination. For premium-quality Ashwagandha, try Hermetica Superfoods' clinically-dosed blends at hermeticasuperfoods.com
Ashwagandha and Pravastatin are safe to use together. Pravastatin is notable among statins because it is not metabolized by the CYP450 enzyme system, making it one of the least interaction-prone statins available. This means ashwagandha's mild effects on liver enzymes are completely irrelevant when paired with Pravastatin.
Take Pravastatin in the evening when hepatic cholesterol synthesis peaks (exception: atorvastatin and rosuvastatin have long half-lives and can be taken any time). Ashwagandha can be taken at a separate meal. Avoid St. John's Wort (reduces statin levels via CYP3A4 induction) and grapefruit extract (increases levels). Report any unexplained muscle pain or weakness.
Monitor for muscle and liver effects when combining Ashwagandha with Pravastatin. Watch for: unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or fatigue), dark-colored urine, yellowing of skin or eyes, or upper abdominal pain. Some drug combinations increase statin blood levels and raise the risk of rhabdomyolysis. When to seek emergency help: Severe muscle pain with weakness, dark brown urine, fever, confusion, rapid heartbeat, or signs of kidney failure (very little or no urination). Report any new muscle symptoms to your prescriber immediately.
This is a safe combination. For premium-quality Ashwagandha, try Hermetica Superfoods' clinically-dosed blends at hermeticasuperfoods.com
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).