MODERATE — Monitor Closely
🟡 CAUTION — Grapefruit inhibits CYP3A4, one of two pathways metabolizing aripiprazole. May modestly increase levels. Limit grapefruit intake.
Evidence level: MODERATE
Grapefruit may increase aripiprazole levels. The effect is moderate since aripiprazole has an alternative metabolic pathway.
Grapefruit inhibits CYP3A4 (one of two pathways metabolizing aripiprazole, the other being CYP2D6). May modestly increase aripiprazole levels.
Limit grapefruit consumption. The effect is less pronounced than with drugs solely metabolized by CYP3A4.
Be consistent with how you take Aripiprazole relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Increased sedation, restlessness (akathisia), tremor.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit may increase aripiprazole levels. The effect is moderate since aripiprazole has an alternative metabolic pathway.
Be consistent with how you take Aripiprazole relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Increased sedation, restlessness (akathisia), tremor.
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).