MODERATE — Monitor Closely
Apigenin and Theophylline — Risk of Theophylline Toxicity
Evidence level: MODERATE
Apigenin blocks the liver enzyme (CYP1A2) that breaks down Theophylline. This could cause Theophylline to build up in your body to dangerous levels, causing nausea, rapid heartbeat, or seizures.
Apigenin is a potent CYP1A2 inhibitor. Theophylline is primarily metabolized by CYP1A2. Inhibition may increase theophylline plasma levels, risking toxicity. Theophylline has a narrow therapeutic index.
IMPORTANT: If you take Theophylline for asthma or COPD, inform your pulmonologist before using Apigenin. Request theophylline level monitoring. Consider avoiding this combination or using very low Apigenin doses.
CYP1A2 inhibition is not eliminated by timing separation. If combining, maintain consistent Apigenin dosing and monitor theophylline levels.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Nausea, vomiting, rapid heartbeat, tremors, restlessness, headache, seizures (signs of theophylline toxicity).
Apigenin inhibits CYP1A2, the primary enzyme for theophylline metabolism. Request drug level monitoring. Discuss alternative calming supplements that do not affect CYP1A2.
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Apigenin blocks the liver enzyme (CYP1A2) that breaks down Theophylline. This could cause Theophylline to build up in your body to dangerous levels, causing nausea, rapid heartbeat, or seizures.
CYP1A2 inhibition is not eliminated by timing separation. If combining, maintain consistent Apigenin dosing and monitor theophylline levels.
Nausea, vomiting, rapid heartbeat, tremors, restlessness, headache, seizures (signs of theophylline toxicity).
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Apigenin inhibits CYP1A2, the primary enzyme for theophylline metabolism. Request drug level monitoring. Discuss alternative calming supplements that do not affect CYP1A2.
Or browse the full interaction database (121,000+ pairs).