MODERATE — Monitor Closely
Apigenin and Lorazepam — Additive Sedation Risk
Evidence level: MODERATE
Apigenin and Lorazepam both work on GABA brain receptors. Together they may cause excessive calming effects including heavy drowsiness.
Additive GABA-A receptor modulation. Both substances enhance GABAergic inhibition in the CNS.
Reduce Apigenin dose when using Lorazepam. Do not take together before activities requiring alertness.
Take Lorazepam only as prescribed. Apigenin (a flavonoid found in chamomile) has mild GABA-ergic and sedative properties — it acts on the same receptor pathway as benzodiazepines. Taking both may amplify sedation. Space at least 4-6 hours apart, and take Apigenin at a lower dose. Avoid driving or operating machinery if using both. Discuss this combination with your prescriber.
Higher risk for: elderly (fall risk, oversedation), those with respiratory conditions, concurrent opioid or alcohol use, liver impairment, history of substance use disorder, or those on multiple CNS depressants.
Heavy sedation, impaired motor function, dizziness, confusion.
Inform your prescriber about Apigenin. Both enhance GABA — discuss appropriate dosing.
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Apigenin and Lorazepam both work on GABA brain receptors. Together they may cause excessive calming effects including heavy drowsiness.
Take Lorazepam only as prescribed. Apigenin (a flavonoid found in chamomile) has mild GABA-ergic and sedative properties — it acts on the same receptor pathway as benzodiazepines. Taking both may amplify sedation. Space at least 4-6 hours apart, and take Apigenin at a lower dose. Avoid driving or operating machinery if using both. Discuss this combination with your prescriber.
Heavy sedation, impaired motor function, dizziness, confusion.
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Inform your prescriber about Apigenin. Both enhance GABA — discuss appropriate dosing.
Or browse the full interaction database (121,000+ pairs).