SAFE — No Known Interaction
🟢 SAFE — Amoxicillin/Clavulanate and Andrographis can be taken together safely.
Evidence level: LIMITED
Amoxicillin/Clavulanate and Andrographis are generally considered safe to use together. No adverse interactions have been reported in medical literature.
No clinically significant interaction between Amoxicillin/Clavulanate and Andrographis has been identified in medical literature.
No interaction documented between Amoxicillin/Clavulanate and Andrographis. Always inform your healthcare provider about everything you take.
Space Andrographis at least 2 hours from Amoxicillin/Clavulanate. Many botanicals contain polyphenols, tannins, and other compounds that can bind antibiotics in the gut and reduce absorption. Follow the antibiotic's specific food instructions. Consider pausing the botanical during short antibiotic courses if uncertain about interactions.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Monitor for altered effectiveness and side effects when combining Amoxicillin/Clavulanate with Andrographis. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
No urgent discussion needed, but keep your provider informed. Say: "I take Amoxicillin/Clavulanate alongside Andrographis — anything I should know?"
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
Amoxicillin/Clavulanate and Andrographis are generally considered safe to use together. No adverse interactions have been reported in medical literature.
Space Andrographis at least 2 hours from Amoxicillin/Clavulanate. Many botanicals contain polyphenols, tannins, and other compounds that can bind antibiotics in the gut and reduce absorption. Follow the antibiotic's specific food instructions. Consider pausing the botanical during short antibiotic courses if uncertain about interactions.
Monitor for altered effectiveness and side effects when combining Amoxicillin/Clavulanate with Andrographis. Antibiotics can affect liver enzymes and alter the blood levels of other medications. Watch for: unusual nausea, vomiting, diarrhea (especially watery or bloody), stomach cramps, skin rash, dizziness, or signs the other medication is working differently than usual. When to seek emergency help: Severe allergic reaction (difficulty breathing, swelling of face/throat, hives), severe or persistent diarrhea (possible C. difficile infection), yellowing of skin or eyes, dark urine, or irregular heartbeat. Complete the full antibiotic course as prescribed.
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
No urgent discussion needed, but keep your provider informed. Say: "I take Amoxicillin/Clavulanate alongside Andrographis — anything I should know?"
Or browse the full interaction database (121,000+ pairs).