MODERATE — Monitor Closely
🟡 MODERATE — Use caution combining grapefruit with Amlodipine.
Evidence level: MODERATE
Grapefruit can increase amlodipine levels, potentially causing your blood pressure to drop too low.
Grapefruit inhibits CYP3A4, increasing amlodipine blood levels and enhancing its blood pressure-lowering effect.
Limit grapefruit consumption. Monitor blood pressure more frequently. Rise slowly from sitting/lying positions.
Be consistent with how you take Amlodipine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Elderly, patients on multiple blood pressure medications
Dizziness, lightheadedness, fainting, ankle swelling
Mention grapefruit consumption when reviewing blood pressure control
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Grapefruit can increase amlodipine levels, potentially causing your blood pressure to drop too low.
Be consistent with how you take Amlodipine relative to meals — take it with food or without food consistently each day. Grapefruit — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Dizziness, lightheadedness, fainting, ankle swelling
Adjust the timing or quantity of Grapefruit relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Mention grapefruit consumption when reviewing blood pressure control
Or browse the full interaction database (121,000+ pairs).