# Ultimine (Ferrous Ferric Iron)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/ultimine
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-29
**Evidence Score:** 2 / 10
**Category:** Mineral
**Also Known As:** Mixed valence iron compound, Fe²⁺/Fe³⁺ iron complex, Ferrous-ferric iron mixture, Dual oxidation state iron, Mixed iron oxidation compound

## Overview

Ultimine is a proprietary iron supplement containing both ferrous (Fe2+) and ferric (Fe3+) iron forms designed for enhanced absorption. The dual-valence formulation aims to optimize iron bioavailability through multiple intestinal transport pathways.

## Health Benefits

• No clinical evidence available - No studies document health benefits specifically for Ultimine
• Iron deficiency treatment potential - General ferrous iron supplements are established for treating iron deficiency, though no data exists for this specific formulation
• No verified [cardiovascular](/ingredients/condition/heart-health) benefits - No clinical trials support cardiovascular claims for Ultimine
• No documented energy support - No research validates energy-related benefits for this compound
• No proven [immune function](/ingredients/condition/immune-support) support - No studies demonstrate immune system benefits for Ultimine

## Mechanism of Action

Ultimine provides ferrous iron (Fe2+) that is directly absorbed via divalent metal transporter 1 (DMT1) in duodenal enterocytes, while ferric iron (Fe3+) requires reduction by duodenal cytochrome B reductase before absorption. The dual-form approach theoretically maximizes iron uptake by utilizing both heme and non-heme iron transport mechanisms. Once absorbed, iron is incorporated into transferrin for systemic distribution to tissues requiring iron for hemoglobin synthesis and cellular respiration.

## Clinical Summary

No clinical trials have specifically evaluated Ultimine's efficacy or safety profile. While general ferrous sulfate and ferric compounds have extensive research supporting their use in iron deficiency anemia treatment, the specific ferrous-ferric combination in Ultimine lacks peer-reviewed clinical validation. Standard iron supplements typically show 10-30% absorption rates and effectively raise hemoglobin levels by 1-2 g/dL over 4-8 weeks in iron-deficient patients. The theoretical advantages of Ultimine's dual-iron formulation remain unproven without dedicated clinical studies.

## Nutritional Profile

Ultimine is a proprietary iron compound containing both ferrous (Fe²⁺) and ferric (Fe³⁺) iron in a combined oxidation state formulation. As a mineral ingredient, it contains no macronutrients (zero protein, fat, or carbohydrates), no dietary fiber, and no vitamins inherently. The active constituent is elemental iron delivered in a mixed-valence form. Typical supplemental iron doses in comparable ferrous/ferric compounds range from 15–65 mg elemental iron per serving, though Ultimine-specific dosing data is not publicly documented. The dual iron state (ferrous + ferric) is theoretically relevant to bioavailability: ferrous iron (Fe²⁺) is the primary absorbable form in the duodenum via divalent metal transporter-1 (DMT-1), while ferric iron (Fe³⁺) requires reduction by duodenal cytochrome B (Dcytb) prior to absorption. The mixed-valence formulation may be designed to optimize this reduction step, potentially improving absorption compared to strictly ferric compounds. No published bioavailability studies specific to Ultimine exist; however, ferrous iron salts generally achieve 10–35% absorption in iron-deficient individuals and 1–10% in iron-replete individuals. No additional micronutrients, phytonutrients, or bioactive compounds are documented for this ingredient beyond the iron content itself.

## Dosage & Preparation

No clinically studied dosages, forms, or standardization are documented for Ultimine. General ferrous sulfate dosing ranges from 200-325 mg elemental iron daily, but this lacks relevance without product-specific data. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Iron supplements commonly cause gastrointestinal side effects including nausea, constipation, and stomach upset, with similar effects expected from Ultimine. Iron absorption decreases significantly when taken with calcium, tea, coffee, or dairy products, while vitamin C enhances absorption. Iron supplements can reduce absorption of tetracycline antibiotics, levothyroxine, and bisphosphonates when taken concurrently. Pregnant women should consult healthcare providers before using iron supplements, as excessive iron intake may cause complications.

## Scientific Research

No clinical trials, RCTs, meta-analyses, or PubMed PMIDs are available for Ultimine as a branded ingredient. The research dossier indicates that while ferrous sulfate is a standard iron supplement with established efficacy, no mixed ferrous-ferric branded studies exist for this specific product.

## Historical & Cultural Context

No historical or traditional medicine uses are documented for Ultimine in systems like Ayurveda or TCM. Iron salts have primarily industrial applications rather than traditional biomedical uses.

## Synergistic Combinations

No synergistic ingredients identified due to lack of research

## Frequently Asked Questions

### What makes Ultimine different from regular iron supplements?

Ultimine contains both ferrous (Fe2+) and ferric (Fe3+) iron forms in a single supplement, theoretically allowing utilization of multiple intestinal absorption pathways. However, no clinical studies have demonstrated superior bioavailability compared to standard ferrous sulfate supplements.

### How much elemental iron does Ultimine provide per dose?

Specific elemental iron content per Ultimine dose is not standardized across manufacturers and should be verified on product labels. Most iron supplements provide 18-65mg elemental iron per dose, representing 100-360% of the recommended daily allowance.

### Can Ultimine cause the same side effects as other iron supplements?

Yes, Ultimine likely causes similar gastrointestinal side effects as other iron supplements, including constipation, nausea, and stomach irritation. The dual iron formulation does not eliminate these common iron-related adverse effects.

### Should Ultimine be taken with food or on an empty stomach?

Like other iron supplements, Ultimine is best absorbed on an empty stomach but may be taken with food to reduce gastrointestinal upset. Taking with vitamin C enhances absorption, while calcium, coffee, and tea significantly reduce iron uptake.

### Is there clinical evidence supporting Ultimine over standard iron supplements?

No published clinical trials have compared Ultimine's efficacy to standard iron formulations like ferrous sulfate or ferrous gluconate. The theoretical benefits of combining ferrous and ferric iron remain unproven without dedicated comparative studies.

### Does Ultimine contain any additional ingredients that enhance iron absorption?

Ultimine is formulated as ferrous ferric iron, a combination form that may offer different absorption characteristics than standard ferrous sulfate, though specific enhancement ingredients are not publicly documented. The branded formulation's exact composition and any absorption-enhancing cofactors should be verified on the product label or manufacturer documentation. Without clinical data comparing Ultimine's absorption rate to standard iron supplements, it's unclear what specific advantages the ferrous ferric combination provides.

### Who should avoid taking Ultimine, and are there specific health conditions that contraindicate its use?

Individuals with hemochromatosis, iron overload disorders, or certain types of anemia should avoid iron supplementation without medical guidance. Those with gastrointestinal conditions like ulcerative colitis or Crohn's disease may experience worsened symptoms from iron supplements. As with all iron products, Ultimine should only be used under healthcare provider supervision, particularly for those with underlying health conditions or taking multiple medications.

### How does the ferrous ferric iron combination in Ultimine differ from ferrous sulfate in terms of bioavailability?

Ultimine's ferrous ferric combination theoretically differs from standard ferrous sulfate by including both ferrous (Fe²⁺) and ferric (Fe³⁺) iron forms, though no published comparative bioavailability studies exist for this specific formulation. Ferrous iron is traditionally considered more readily absorbed than ferric iron in the gastrointestinal tract, but the practical advantage of combining both forms in Ultimine remains unproven. Without clinical evidence, it cannot be definitively stated whether this combination improves overall iron absorption compared to established ferrous sulfate supplements.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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