# Tienchi Ginseng (Panax notoginseng)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/tienchi-ginseng
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-04-01
**Evidence Score:** 2 / 10
**Category:** Traditional Chinese Medicine
**Also Known As:** Panax notoginseng, Sanqi, San Qi, Notoginseng, Chinese Ginseng, Pseudoginseng, Sanchi Ginseng, Three-Seven Root, Tianqi, Radix Notoginseng, Pseudoginseng Root

## Overview

Panax notoginseng is a Chinese medicinal herb containing saponins called notoginsenosides that support [cardiovascular health](/ingredients/condition/heart-health) and blood circulation. The primary compounds notoginsenoside R1 and ginsenoside Rg1 work through platelet aggregation inhibition and vascular protection mechanisms.

## Health Benefits

• Provides protection against cerebrovascular disease (evidence from in vitro and animal studies). • Promotes blood circulation based on TCM theory (historical use). • Offers hemostatic benefits, aiding in stopping bleeding (traditional use). • Enhances vitality and resolves blood stasis according to historical applications. • Supports immune and nervous system functions through saponin effects (preliminary evidence).

## Mechanism of Action

Notoginsenosides R1 and Rb1 inhibit platelet aggregation by reducing thromboxane A2 production and increasing nitric oxide synthesis. Ginsenoside Rg1 protects vascular endothelium by activating eNOS pathways and reducing [inflammatory](/ingredients/condition/inflammation) cytokines like TNF-α. These compounds also modulate calcium channels and improve microcirculation through vasodilation.

## Clinical Summary

Most evidence comes from in vitro and animal studies showing [cardiovascular](/ingredients/condition/heart-health) protective effects. Small human trials (20-60 participants) suggest benefits for blood circulation and platelet function, but larger controlled studies are needed. Traditional use spans centuries in TCM for bleeding disorders and blood stasis, though clinical validation remains limited. Current research focuses on stroke prevention and recovery applications.

## Nutritional Profile

Tienchi Ginseng (Panax notoginseng) root powder (per 100g dry weight): Protein: 12–15g (contains all essential amino acids, notably arginine ~1.2g, glutamic acid ~1.8g, aspartic acid ~1.1g); Total Carbohydrates: 55–65g (including polysaccharides 8–12g, monosaccharides glucose and fructose ~3–5g); Dietary Fiber: 8–12g; Fat: 1–2g (low lipid content, trace essential fatty acids); Moisture (dried): 8–12%. Key Bioactive Compounds: Saponins (total ginsenosides/notoginsenosides): 6–12g per 100g — primary actives include Notoginsenoside R1 (~0.5–2.0%), Ginsenoside Rb1 (~1.0–3.0%), Ginsenoside Rd (~0.5–1.5%), Ginsenoside Rg1 (~1.0–3.5%), and Ginsenoside Re (~0.3–1.0%); Dencichine (beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, ODAP): 0.3–0.9g per 100g — primary hemostatic alkaloid; Panaxatriol and Panaxadiol aglycone backbones present as saponin precursors; Flavonoids (quercetin, kaempferol glycosides): ~200–400mg per 100g; Polyphenols (total): ~300–600mg per 100g; Minerals: Calcium 120–180mg, Iron 8–15mg, Zinc 2–4mg, Manganese 3–6mg, Phosphorus 200–280mg, Potassium 1,200–1,800mg, Magnesium 80–120mg per 100g; Vitamins: Vitamin C trace (~5–15mg per 100g in fresh root, largely degraded in dried/processed forms), B-complex vitamins at low concentrations (B1 ~0.1mg, B2 ~0.15mg, niacin ~1.5mg per 100g); Amino acid taurine: trace amounts reported; Phytosterols (beta-sitosterol, stigmasterol): ~50–100mg per 100g. Bioavailability Notes: Saponin bioavailability is moderate (estimated 10–30% oral absorption); gut microbiota metabolizes ginsenosides into more bioactive compound K and protopanaxadiol forms, enhancing systemic effect; Dencichine is water-soluble and relatively well-absorbed but heat-labile; polysaccharides exert [prebiotic](/ingredients/condition/gut-health) and [immunomodulatory](/ingredients/condition/immune-support) effects largely in the GI tract; co-administration with warm water or alcohol tincture preparations increases saponin extraction efficiency; standardized extracts typically normalized to ≥5% total saponins for therapeutic dosing.

## Dosage & Preparation

No clinically studied dosage ranges are available due to the absence of human trial data. Standardized extracts require total saponins content of ≥75%. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Generally well-tolerated but may increase bleeding risk when combined with anticoagulants like warfarin or aspirin. Common side effects include mild gastrointestinal upset and dizziness at higher doses. Contraindicated during pregnancy and breastfeeding due to insufficient safety data. Should be discontinued 2 weeks before surgery due to potential bleeding complications.

## Scientific Research

There is a lack of specific human clinical trials, RCTs, or meta-analyses for Panax notoginseng. The research primarily includes in vitro and animal studies, with no PMIDs available for significant human trials.

## Historical & Cultural Context

In Traditional Chinese Medicine, Panax notoginseng has been used for over 400 years to promote blood circulation and stop bleeding. It is particularly valued for treating traumatic injuries and cerebrovascular issues.

## Synergistic Combinations

Ginkgo biloba, Astragalus, Reishi mushroom, Rhodiola, Turmeric

## Frequently Asked Questions

### What is the difference between Panax notoginseng and regular ginseng?

Panax notoginseng contains unique notoginsenosides (R1, R2, R3) not found in Panax ginseng, giving it distinct cardiovascular benefits. While regular ginseng focuses on adaptogenic effects, notoginseng specializes in blood circulation and hemostatic properties.

### How much Panax notoginseng should I take daily?

Traditional doses range from 3-9 grams of raw root powder daily, while standardized extracts typically use 200-400mg containing 10-20% notoginsenosides. Start with lower doses and consult a healthcare provider, especially if taking blood-thinning medications.

### Can Panax notoginseng help with stroke recovery?

Animal studies show notoginsenosides may protect brain tissue and improve blood flow after stroke. However, human clinical trials are limited and more research is needed to confirm therapeutic benefits for stroke patients.

### Is Panax notoginseng safe to take with blood pressure medications?

Notoginseng may enhance the effects of blood pressure medications due to its vasodilatory properties. Monitor blood pressure closely and consult your doctor before combining, as dose adjustments may be necessary.

### How long does it take to see benefits from Panax notoginseng?

Acute effects on blood circulation may occur within hours, while cardiovascular protective benefits typically develop over 4-8 weeks of consistent use. Traditional Chinese medicine suggests 3-month cycles for optimal blood stasis resolution.

### Is Panax notoginseng safe during pregnancy and breastfeeding?

Panax notoginseng is traditionally used to promote blood circulation and stop bleeding, but its safety during pregnancy and breastfeeding has not been adequately studied in clinical trials. Due to its hemostatic and circulatory effects, pregnant and breastfeeding women should consult a healthcare provider before use, as it may have unintended effects on pregnancy or milk composition. Most medical professionals recommend avoiding Panax notoginseng during these periods unless specifically recommended by a qualified practitioner familiar with both the supplement and the individual's health status.

### What form of Panax notoginseng is most effective—powder, extract, or whole root?

Panax notoginseng is available as whole root, powder, and concentrated extracts, with standardized extracts typically offering more consistent saponin content and bioavailability than whole root preparations. The powder form allows for flexible dosing but may have lower absorption rates compared to extracts, which concentrate the active compounds. Concentrated extracts are generally preferred for clinical research and therapeutic applications because they provide measurable levels of ginsenosides and notoginsenosides, the primary bioactive compounds responsible for the herb's cardiovascular and immune-supporting effects.

### Does Panax notoginseng interact with anticoagulant or antiplatelet medications like warfarin or aspirin?

Panax notoginseng has mild anticoagulant and antiplatelet properties due to its saponin content, which may potentiate the effects of blood-thinning medications like warfarin and aspirin. Combined use could increase bleeding risk, and case reports suggest additive effects when taken concurrently with these medications. Anyone taking anticoagulants or antiplatelet drugs should inform their healthcare provider before using Panax notoginseng and obtain professional guidance on safe concurrent use.

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